Apelin/APJ： a novel therapy target for inflammation-related diseases  

出　　处：《中国药理学通报》2015年第B11期36-36,共1页Chinese Pharmacological Bulletin

摘　　要：Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors, expressed in a variety of tissues in vivo and involved in the physiological and pathological processes. Studies had shown that ape- lin/APJ system was involved in the regulation of cardiovascular function, insulin sensitivity and had a close connec- tion with oxidative stress and inflammatory cytokines. Therefore, this article summarized that apelin/APJ system such as atherosclerosis, hyperten- had the effects of inflammation-related diseases associated with oxidative stress, ischemia-reperfusion injury, tumour and pre-eclampsia, etc. sion, diabetes and its mierovaseular complications, Meanwhile the drugs targeted apelin/APJ was introduced in order to provide the novel therapeutic strategy for in- flammation-related diseases.

关 键 词：APELIN APJ oxidative stress reactive oxygen species (ROS) INFLAMMATION ATHEROSCLEROSIS hyper-tension ISCHEMIA-REPERFUSION injury 

分 类 号：R[医药卫生]