An immortalized rat pancreatic stellate cell line RP-2 as a new cell model for evaluating pancreatic fibrosis,inflammation and immunity  

作　　者：Rong-Li Piao Ming Xiu David R Brigstock Run-Ping Gao 

机构地区：[1]Department of Hepatic-biliary-pancreatic Medicine,the First Hospital of Jilin University [2]The Research Institute at Nationwide Children's Hospital [3]Division of Pediatric Surgery,Department of Surgery,the Ohio State University

出　　处：《Hepatobiliary & Pancreatic Diseases International》2015年第6期651-659,共9页国际肝胆胰疾病杂志（英文版）

基　　金：support by grants from the National Natural Science Foundation of China(81070370 and 81270544)

摘　　要：BACKGROUND： Pancreatic stellate cells （PSCs） play a critical role in the pathogenesis of pancreatic fibrosis and have emerging functions as progenitor cells, immune cells or intermediaries in pancreatic exocrine secretion. Increasing evidence has shown that desmin as an exclusive cytoskeleton marker of PSC is only expressed in part of these cells. This study was to establish a desmin-positive PSC cell line and evaluate its actions on pancreatic fibrosis, inflammation and immunity.BACKGROUND： Pancreatic stellate cells （PSCs） play a critical role in the pathogenesis of pancreatic fibrosis and have emerging functions as progenitor cells, immune cells or intermediaries in pancreatic exocrine secretion. Increasing evidence has shown that desmin as an exclusive cytoskeleton marker of PSC is only expressed in part of these cells. This study was to establish a desmin-positive PSC cell line and evaluate its actions on pancreatic fibrosis, inflammation and immunity.

关 键 词：pancreatic stellate cell pancreatic fibrosis Toll-like receptor 4 INFLAMMATION IMMUNITY 

分 类 号：R576[医药卫生—消化系统]