Exploiting the inherent invasive property to treat glioblastoma multiforme  

作　　者：ZHANG Feng LIAO Heng 

机构地区：[1]Department of Pathology, Xijing Hospital, Basic Medical College, State Key Laboratory of Cancer Biology, Fourth Military Medical University [2]Health Center,Unit 68094, Branch 28, Lanzhou Military Area Command

出　　处：《医学争鸣》2015年第6期26-27,共2页Negative

基　　金：Supported by the National Natural Science Foundation of China(31000559)

摘　　要：Glioblastoma multiforme(GBM)is the most malignant brain tumor with high infiltration.The routine surgical resection followed by radiation and chemotherapy only provides patients with a survival period ranging 12–15months.Here,I propose that the high invasiveness property of the GBM cells be exploited to treat this deadly disease.That is,instead of inhibiting the dissemination of GBM cells,we should take advantage of the high mobility of the disseminated GBM cells and directionally induce these cells to return to the center of surgical resection cavity of the primary neoplasm and subsequently kill them.This idea may provide a new promise to defeat this deadly disease.Glioblastoma multiforme （GBM） is the most malignant brain tumor with high infiltration. The routine surgical resection followed by radiation and chemotherapy only provides patients with a survival period ranging 12- 15 months. Here, I propose that the high invasiveness property of the GBM cells be exploited to treat this deadly disease. That is, instead of inhibiting the dissemination of GBM cells, we should take advantage of the high mobility of the disseminated GBM cells and directionally induce these cells to return to the center of surgical resection cavity of the primary neoplasm and subsequently kill them. This idea may provide a new promise to defeat this deadly disease.

关 键 词：GLIOBLASTOMA MULTIFORME INFILTRATION treatment RESECTION cavity 

分 类 号：R739.4[医药卫生—肿瘤]