Co-infection of Epstein-Barr virus and human papillomavirus in human tumorigenesis  

作　　者：Ying Shi Song‑Ling Peng Li‑Fang Yang Xue Chen Yong‑Guang Tao Ya Cao 

机构地区：[1]Cancer Research Institute,Central South University,Changsha 410078,Hunan,P.R.China [2]Key Laboratory of Carcinogenesis and Cancer Invasion,Ministry of Education,Changsha 410078,Hunan,P.R.China [3]Key Laboratory of Carcinogenesis,National Health and Family Planning Commission,Changsha 410078,Hunan,P.R.China

出　　处：《Chinese Journal of Cancer》2016年第3期100-108,共9页

基　　金：supported by the National Basic Research Program of China[2011CB504300(Y.T.;Y.C.),2015CB553903(Y.T.)];the National High Technology Research and Development Program of China(863 Program)[2012AA02A501(Y.C.)];the National Natural Science Foundation of China[81,171,881 and81372427(Y.T.),81271763(S.L.),81,302,354(Y.S.)];the Hunan Natural Science Foundation of China[12JJ1013(Y.T.)]

摘　　要：Viral infections contribute to approximately 12%of cancers worldwide,with the vast majority occurring in developing countries and areas.Two DNA viruses,Epstein-Barr virus(EBV) and human papillomavirus(HPV),are associated with38%of all virus-associated cancers.The probability of one patient infected with these two distinct types of viruses is increasing.Here,we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis.Viral infections contribute to approximately 12%of cancers worldwide,with the vast majority occurring in developing countries and areas.Two DNA viruses,Epstein-Barr virus(EBV) and human papillomavirus(HPV),are associated with38%of all virus-associated cancers.The probability of one patient infected with these two distinct types of viruses is increasing.Here,we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis.

关 键 词：EPSTEIN-BARR virus  Human papillomavirus  Co-infection  NASOPHARYNGEAL carcinoma  Cervical cancer Breast cancer  Prostate CANCER 

分 类 号：R730.2[医药卫生—肿瘤]