鸡蛋壳制备的谷氨酸螯合钙片剂配方及工艺研究  

Optimization of formulation and preparation process for glutamate chelating calcium tablets

作　　者：胡荣[1] 马宇熙[2] 陈铮[1] 乔峰[1] 李瑾瑜[1] 王子荣[1] 

机构地区：[1]新疆农业大学食品科学与药学学院,新疆乌鲁木齐830052 [2]乌鲁木齐市疾病预防控制中心,新疆乌鲁木齐830026

出　　处：《食品工业科技》2016年第7期258-262,309,共6页Science and Technology of Food Industry

基　　金：研究生创新项目(XJAUGRI2015012)

摘　　要：研究以鸡蛋壳为原材料制备的谷氨酸螯合钙片剂成型的配方及工艺。采用粉末直接压片法,在单因素的基础上,根据Box-Behnken的原理设计,以谷氨酸螯合钙、微晶纤维素、羟丙基甲基纤维素、微粉硅胶的添加量为响应因素,片剂综合评分指标为响应值,进行谷氨酸螯合钙片制备工艺优化的响应面实验。实验结果表明片剂各组分最佳添加量为:谷氨酸螯合钙40.57%、微晶纤维素40.88%、羟丙基甲基纤维素20.16%、微粉硅胶1.54%。在最佳条件下,片剂的综合评分为9.99分,与预测值10.00分吻合较好,实验最优配方制得的谷氨酸螯合钙片剂表面光滑、色泽均匀、不易裂片、溶解性能好。这不仅降低了氨基酸螯合钙片剂原材料的成本,同时也为钙制剂的研制提供了参考。The preparation process of glutamate chelating calcium tablets were studied, and egg shells was taken as material.In the experiment,tablets were made by pressing powder directly.On the basis of the single factor experiments,the preparation process of glutamate chelating calcium tablets was optimized using Box-Behnken. The amounts of glutamate chelating calcium,microcrystalline cellulose, hydroxypropyl methylcellulose and micro- silica were taken as response factors, composite indicator as response surface value.The results showed that the optimal addition of main material and accessories were as follows： glutamate chelating calcium 40.57%, microcrystalline cellulose 40.88%, hydroxypropyl methylcellulose 20.16%, micro- silica t.54% and the comprehensive score of the tablets was 9.99,which was in good agreement with the predict value of 10.00.The glutamate chelating calcium tablets made with optimum formula were characterized by smooth surface, uniform colour and lustre, good molding ability, good solubility, which didn＇ t only save the cost of raw materials for the amino acid chelate calcium tablets, but also provided reference for the development of calcium preparations.

关 键 词：谷氨酸螯合钙 片剂 响应面 工艺 

分 类 号：TS253.9[轻工技术与工程—农产品加工及贮藏工程]