食品中氨基糖苷类残留前处理及分析方法研究进展  

Research Progress on Pretreatment Technologies and Detection Methods of Aminoglycosides Residues in Food

作　　者：张元[1,2] 周昱[2] 周伟娥[1] 李绍辉[1] 郑阳[1] 张峰[1] 

机构地区：[1]中国检验检疫科学研究院食品安全研究所,北京100176 [2]中国医科大学药学院,沈阳110013

出　　处：《食品工业》2016年第4期223-227,共5页The Food Industry

基　　金：国家重大科学仪器设备开发专项项目(2012YQ14000806);国家质检总局科技计划专项(2014Ik084);北京市科技计划课题(Z141100002614020);辽宁省科学技术厅自然科学基金(201202252)

摘　　要：氨基糖苷类兽药残留是目前重要的动物源性食品安全问题之一,检测食品中氨基糖苷类残留对人体健康具有重要的意义。检测食物基质中痕量兽药残留依赖于有效的前处理方法和精密的分析仪器。阐述了氨基糖苷类兽药的研究背景和现状,并对国内外食品中氨基糖苷类兽药残留的液-液萃取、固相萃取等前处理方法及液相色谱质谱法、液相色谱法、毛细管电泳分析方法及免疫分析测定法等检测方法进行了综述,拟为动物源性食品中氨基糖苷类药物的残留监控提供参考。综述指出SPE为最有前景的前处理方法,而质谱技术的发展和仪器的小型化为检测仪器的发展趋势。Aminoglycosides residue is currently an important problem in animal derived food safety, and the detection of aminoglycosides is of great significance for protecting people. The detection of aminoglycosides in a complex food matrix mainly relies on an effective pretreatment method and precision instruments. Summarize the research background and status of aminoglycosides, and review the research progress in China and other countries on pretreatment technologies, such as liquid-liquid extraction, solid-phase extraction and detection methods, such as high performance liquid chromatographytandem mass, high performance liquid chromatography, capillary electrophoresis and immunoassay. It is provided the reference of monitoring aminoglycosides residues in food. It is indicated that SPE is the most promising pretreatment method, and the development of mass-spectrometric technique and the miniaturization of instrument will be a development trend.

关 键 词：动物源性食品 前处理技术 检测 氨基糖苷类 

分 类 号：TS207.53[轻工技术与工程—食品科学]