Chemokines and their receptors in lung cancer progression and metastasis  

趋化因子及其受体在肺癌侵袭与转移过程中的作用（英文）

作　　者：Zeng-hui CHENG Yu-xin SHI Min YUAN Dan XIONG Jiang-hua ZHENG Zhi-yong ZHANG 

机构地区：[1]Department of Radiology, Shanghai Public Health Clinical Center, Fudan University [2]Department of Radiology, Qingpu Branch of Zhongshan Hospital, Fudan University [3]Department of Clinical Laboratory, Shanghai Public Health Clinical Center, Fudan University

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2016年第5期342-351,共10页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project supported by the Science and Technology Commission of Shanghai Municipality(No.14140901400);the Natural Science Foundation of Shanghai(No.13ZR1435000);the National Natural Science Foundation of China(No.81372318)

摘　　要：Lung cancer is the leading cause of cancer-related mortality around the world. Despite advancements in diagnosis, surgical techniques, and neoadjuvant chemoradiotherapy over the last decade, the mortality rate is still high and the 5-year survival is a dismal 15%. Fortunately, early detection by low-dose computed tomography （LDCT） scans has reduced mortality by 20%; yet, overall, 5-year-survival remains low at less than 20%. Therefore, in order to ame- liorate this situation, a thorough understanding of the underlying molecular mechanisms is urgently needed. Chemo- kines and their receptors, crucial microenvironmental factors, play important roles in lung tumor genesis, progression, and metastasis, and exploring the mechanisms of this might bring new insights into early diagnosis and precisely targeted treatment. Consequently, this review will mainly focus on recent advancements on the axes of chemokines and their receptors of lung cancer.本文对近年来与肺癌侵袭、转移相关的趋化因子轴及其可能的机制进行综述,为靶向治疗提供理论线索,并预测促癌趋化因子轴的激活与抑癌趋化因子轴的失活可能导致了肺癌的侵袭与转移。

关 键 词：Lung cancer CHEMOKINES Tumor progression METASTASIS 

分 类 号：R734.2[医药卫生—肿瘤] R34[医药卫生—临床医学]