头颈部组织样品微尺度力学的原子力显微镜检测  

Nanomechanical Detection of Living Head and Neck Tissue Samplesby Atomic Force Microscopy

作　　者：王洲[1] 李静[2] 高警蔚 韩鑫晓 华闻达 刘仲奇[1] 韩东[2] 

机构地区：[1]北京大学第三医院,北京100191 [2]国家纳米科学中心,北京100190

出　　处：《影像科学与光化学》2016年第3期288-296,共9页Imaging Science and Photochemistry

基　　金：国家自然科学基金面上项目(31470905)资助

摘　　要：肿瘤及微环境的力学性质改变是肿瘤发生、发展的基本生物学特征之一,其中,刚度是重要的参数。本文利用原子力显微镜对头颈部的组织样品进行了微区力学研究,并将采集的组织刚度信息,转换成刚度分布图,尝试采用刚度分布图中软硬过渡界面曲率对样品的力学特性进行分析,建立了头颈部组织原位力学特性的分析方法,有望为头颈部良恶性病变提供一个诊断研究的新方法与新思路,以弥补病理学检查中存在的缺乏定量标准和样品制备周期长等不足。The biomechanical change in tumor and its microenvironment is one of the basic biological characteristics,which plays a key role in the processin oncogenesis and development of tumor.The stiffness is a more important biomechanical feature.In this paper,AFM is employed to address the nanomechanical properties of the living tissue sample from head and neck.Furthermore,the stiffness information is converted into the stiffness distribution.Then the curvature of the interface among different stiffness regions is analyzed.In situ analysis of mechanical properties of living head and neck tissue samples is expected to provide a diagnosis of benign and malignant lesions of the head and neck tissues.

关 键 词：头颈部组织 微尺度力学 刚度 原子力显微镜 曲率 

分 类 号：R739.91[医药卫生—肿瘤] R730.43[医药卫生—临床医学]