葡萄糖酸钠铁合成工艺优化及表征  

Optimization of Synthesis Process and Characterization of Sodium Ferric Gluconate Complex

作　　者：马怡璇 王文婷[1] 吴姣娇 潘红春[1] 刘红[1] 

机构地区：[1]西南大学药学院,重庆药物过程与质量控制工程技术研究中心,重庆400715

出　　处：《食品科学》2016年第12期46-51,共6页Food Science

基　　金：重庆市制药过程与质量控制工程技术研究中心能力提升项目(CSTC2012gg-yyjsb10002-33);西南大学博士基金项目(SWU110056;SWU110057)

摘　　要：通过监测葡萄糖酸钠铁合成反应过程变化,得出pH值对产物的含铁量及产量有显著影响。采用控制反应过程pH值来制备葡萄糖酸钠铁并考察比生成速率、含铁量、产率等参数,筛选出最优的反应工艺条件为控制反应过程pH 11.0反应2 h。结果得最大含铁量为29.9%,产率提升至129.12%,粒径减小了58.77%,反应时间缩短了33.33%。通过工艺结果比较,得出葡萄糖酸钠铁的合成是络合、分离再聚集的过程。表征分析验证了控制pH值条件下生成产物确为葡萄糖酸钠铁复合物,且络合铁特征不变。结果发现控制反应pH值可有效优化葡萄糖酸钠铁的制备工艺,实现高产量和高含铁量的统一,具有较高的应用价值。By monitoring the synthetic reaction of sodium ferric gluconate complex, pH value was found to have a significant impact on the iron content and yield of product. Under controlled pH conditions, specific production rate, iron content and yield of sodium ferric gluconate complex were investigated. The maximum iron content of 29.9% and the maximum yield of 129.12% were obtained when the reaction proceeded for 2 h with pH controlled at 11.0. Meanwhile, a 58.77% reduction in the particle size of sodium ferric gluconate complex as well as a 33.33% decrease in reaction time was found compared to that without pH control. Comparative analysis revealed that the synthetic reaction of sodium gluconate iron complex was a process involving complexation, separation and re-aggregation. The results of characterization confirmed the product under controlled pH condition to be sodium ferric gluconate complex with no change in iron-chelating capacity. Therefore, it has been found that pH control provides an effective and applicable approach towards the optimization of the preparation process of sodium ferric gluconate complex for achieving high yield and iron content simultaneously.

关 键 词：葡萄糖酸钠铁 控制pH值 反应过程 比生成速率 优化 

分 类 号：R914.1[医药卫生—药物化学]