喹唑啉类化合物抗癌活性研究进展  

Research Progress in Quinazoline Derivatives with Anticancer Activity

作　　者：李鹏程[1] 刘刚[1] 曹琨[1] 孙林[1] 温全武[1] 

机构地区：[1]鲁东大学化学与材料科学学院,山东烟台264025

出　　处：《中国药学杂志》2016年第11期867-874,共8页Chinese Pharmaceutical Journal

基　　金：山东省自然科学基金资助项目(ZR2013BM006)

摘　　要：喹唑啉环是一种优势骨架结构,可与多种生物大分子结合,产生不同的生物活性,特别是喹唑啉类化合物在抗肿瘤药物研究领域表现尤为突出。通过查阅国内外相关文献,综述近5年来具有抗癌活性的喹唑啉类化合物的国内外研究进展,按照不同喹唑啉环类型分为5类,分别介绍了各类含喹唑啉环化合物的抗癌生物活性,以便更好地利用现有条件设计合成出活性更好选择性更高的抗癌药物。Quinazoline ring, as a key skeleton structure, can produce a variety of biological activities after combining with multi- kinds of biological macromolecules. Quinazoline compounds have played particularly important roles in the discovery of anticancer drugs. The progress in quinazoline derivatives with anticancer activity was reviewed in this paper. Quinazoline compounds were classified into five types according to different substituent groups. The bioactivities of substituent groups containing quinazoline ring were discussed. And the development trend as well as the prospect of quinazoline derivatives with anticancer activity is summarized.

关 键 词：喹唑啉 喹唑啉酮 抗癌活性 生物活性 

分 类 号：R979.1[医药卫生—药品] P014[医药卫生—药学]