1,2,3-三氮唑-马来酰亚胺类化合物的合成及抑菌活性研究  

Synthesis and Biological Evaluation of Novel 1,2,3-Triazole-Maleimide Derivatives

作　　者：徐桂清[1] 赵靓琳 姜玉钦[1] 贾淑红[1] 董文佩 毛龙飞[1] 李伟[1] 

机构地区：[1]河南师范大学化学化工学院河南省化学制药及生物医用材料工程实验室,河南新乡453007

出　　处：《化学试剂》2016年第7期617-620,636,共5页Chemical Reagents

基　　金：河南省重点科技攻关项目(152102310312);河南师范大学青年骨干教师项目(2010)

摘　　要：通过Click反应,将1,2,3-三氮唑和马来酰亚胺结合在一个分子中,合成了一系列新化合物,并通过IR,NMR及HR-MS对其结构进行了确证。对目标化合物体外抑菌活性进行了初步测定。结果表明,部分化合物对细菌金黄色葡萄球菌和大肠杆菌有较强的抑制作用,对真菌葡萄炭疽病原菌有中等抑制作用。A series of novel molecules containing 1,2,3-triazole and maleimide moieties were synthesized via Click reaction. The structures of the target compounds were confirmed by IR,NMR and HR-MS. All the target compounds were tested for qualitative（ Zone of inhibition） or quantitative（ Inhibition rate） antimicrobial activities against two pathogenic bacteria such as Staphylococcus aureus and Escherichia coli and a pathogenic fungi such as Colletotrichum gloeosporioides. The investigation of antimicrobial screening data revealed that most of the tested compounds are moderate microbial inhibitors.

关 键 词：三氮唑 马来酰亚胺 CLICK反应 合成 抑菌活性 

分 类 号：R914.2[医药卫生—药物化学]