山东汉族人群NLRP3基因rs2027432位点多态性与子痫前期遗传易感性的相关性  

ASSOCIATION OF RS2027432 SNP IN NLRP3 WITH PREECLAMPSIA IN CHINESE HAN POPULATION OF SHANDONG PROVINCE

作　　者：李赛[1] 王敬丽[2] 徐龙强[3] 李晓云 刘世国[2] 王修海[1] 

机构地区：[1]青岛大学医学院生物学教研室,山东青岛266071 [2]青岛大学附属医院产前诊断中心 [3]青岛大学附属医院急诊化验室 [4]临沂市妇幼保健院产科

出　　处：《青岛大学医学院学报》2016年第3期338-340,344,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨NLRP3基因rs2027432位点多态性与山东汉族人群子痫前期发病的关系。方法采用实时荧光定量PCR技术,检测976例子痫前期病人和1 194例正常妊娠孕妇的NLRP3基因rs2027432位点多态性分布。结果 NLRP3基因rs2027432位点的基因型和等位基因分布在子痫前期组和对照组之间差异无显著性(P>0.05)。但NLRP3基因3种基因型在早发型子痫前期组和对照组之间差异有统计学意义(χ2=6.384,P<0.05)。结论山东汉族人群NLRP3基因rs2027432位点多态性与早发型子痫前期的发生有关联。Objective To investigate the association between NLRP3rs2027432 and preeclampsia in Chinese Han population of Shandong province. Methods Applying real-time PCR,polymorphisms distribution of rs2027432 locus in NLRP3 gene were detected in 976 patients with preeclampsia and 1 194 normal pregnant women. Results The differences in genotype and allele distribution of rs2027432 locus in NLRP3 gene between preeclampsia group and normal control group were not significant（P〉0.05）,but the differences in the three genotypes of NLRP3 between early-onset preeclampsia and normal control group were significant（χ2=6.384,P〈0.05）. Conclusion There is a correlation between NLRP3rs2027432 and early-onset preeclampsia in Chinese Han population of Shandong province.

关 键 词：基因 NLRP3 多态性 单核苷酸 先兆子痫 疾病遗传易感性 

分 类 号：R714.244[医药卫生—妇产科学] R363.25[医药卫生—临床医学]