颅缝早闭与斜视  

Craniosynostosis and strabismus

作　　者：王安肯 亢晓丽[1] 

机构地区：[1]上海交通大学医学院附属新华医院眼科,200092

出　　处：《中华眼科杂志》2016年第8期626-630,共5页Chinese Journal of Ophthalmology

摘　　要：颅缝早闭（CS）是因颅骨骨缝过早闭合、颅骨发育提前停止而导致的头颅畸形.其分为非综合征型CS和综合征型CS.非综合征型CS仅累及颅骨,根据累及颅缝的不同而产生不同的颅骨畸形;而综合征型CS畸形还累及面部及四肢等,常见的综合征型CS有Crouzon综合征、Apert综合征、Pfeiffer综合征等.CS的临床表现主要包括头颅畸形、高颅内压、脑疝、脑功能发育障碍、斜视等,而综合征型CS的临床表现则更为复杂.目前随着多学科合作的日益完善,CS伴发的眼部疾病,如斜视等,逐步为眼科医师所认识.本文着重从CS的临床表现、并发斜视情况、发病机制、多学科治疗等几个方面进行综述,为临床工作提供参考.Craniosynostosis（CS）,the premature fusion of cranial sutures leading to an abnormal shape and precocious maturity of skull,is classified into Non-syndromic Craniosynostosis （NSC） and Syndromic Craniosynostoses（SC）.NCS only has different abnormality of skull according to which cranial suture is involved while extra malformation of midface and limbs present in SCS.Common SCS contains Crouzon Syndrome,Apert Syndrome,Pfeiffer Sydrome,and etc.The clinical manifestation of CS includes malformation of skull,intracranial hypertension,brain hernia,developmental disorder of cerebral function,strabismus,and etc,while SCS has more complex manifestation.Along with the improvement of multidisciplinary cooperation,the ophthalmic complication of CS,like strabismus,is recognised by oculists gradually.This review is summarizing the clinical manifestation,complicated strabismus,pathogenesis and multidisciplinary cure of CS.

关 键 词：颅缝早闭 斜视 颅面骨发育不全 尖头并指(趾)畸形 

分 类 号：R777.41[医药卫生—眼科]