LuxS/AI-2型群体感应系统调控细菌生物被膜形成研究进展  

Progress in Research on Biofilm Formation Regulated by LuxS/AI-2 Quorum Sensing

作　　者：刘蕾[1] 桂萌[2] 武瑞赟[1,3] 李平兰[1] LIU Lei GUI Meng WU Ruiyun LI Pinglan(Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering,China Agricultural University, Beijing 100083, China Beijing Fisheries Research Institute, Beijing 100068, China College of Life Sciences, Inner Mongolia University, Hohhot 010021, China)

机构地区：[1]中国农业大学食品科学与营养工程学院,北京食品营养与人类健康高精尖创新中心,北京100083 [2]北京市水产科学研究所,北京100068 [3]内蒙古大学生命科学学院,内蒙古呼和浩特010021

出　　处：《食品科学》2016年第19期254-262,共9页Food Science

基　　金：国家自然科学基金面上项目(31271827;31471707;31671831);北京市自然科学基金项目(6164033)

摘　　要：生物被膜是大多数细菌在自然状态下的一种生长方式,使菌体具有浮游态时不具有的优势。它的形成和发展受到群体感应系统的调控,该系统是细菌依赖于群体密度而调控其生理行为的一种机制。其中Lux S/2型自诱导物(autoinducer 2,AI-2)群体感应系统又称种间群体感应系统,广泛存在于G^(+)及G^-菌中。其信号分子AI-2被认为是种间通用的信号分子,参与调控多种细菌的生物被膜。此外,目前已发现多种Lux S/AI-2型群体感应系统抑制剂,它们可以影响许多细菌生物被膜的形成。目前研究人员已开始致力于揭示Lux S/AI-2型群体感应系统调控生物被膜形成的分子机制,这对于进一步理解Lux S/AI-2型群体感应系统与生物被膜的关系具有重要意义。The majority of bacteria form biofilms for growth and development and bacteria within biofilms may better adaptto environment than their planktonic counterparts. LuxS-dependent quorum sensing is a widespread system used by bacteriafor cell-to-cell communication, which can regulate biofilm formation in a cell density-dependent manner. Autoinducer 2 （AI-2）produced by LuxS, is a species-nonspecific signal used by both gram-negative and gram-positive bacteria for biofilmformation. Currently, several inhibitors of LuxS/AI-2 quorum sensing have been determined to influence biofilm formationbased on their anti-AI-2 communication mechanisms. Recently, there has been a surging interest in the mechanism of biofilmregulation by LuxS/AI-2 quorum sensing system, which is important to better understand the relationship between LuxSdependentQS system and biofilm formation.

关 键 词：生物被膜 LuxS/AI-2型群体感应系统 2型自诱导物 群体感应抑制剂 调控机制 

分 类 号：Q939.99[生物学—微生物学]