GPx4基因rs4807542位点多态性与子痫前期遗传易感性的关系  

POLYMORPHISM OF RS4807542 IN GPx4 GENE AND GENETIC SUSCEPTIBILITY TO PREECLAMPSIA

作　　者：林岩[1] 林萍[2] 韩萌萌[3] 王敬丽[3] 刘世国[3] 初开秋[1] 

机构地区：[1]青岛大学附属医院检验科,山东青岛266003 [2]青岛大学附属医院产科,山东青岛266003 [3]青岛大学附属医院产前诊断中心,山东青岛266003

出　　处：《青岛大学医学院学报》2016年第4期422-424,428,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨谷胱甘肽过氧化物酶4(GPx4)基因rs4807542位点单核苷酸多态性与子痫前期遗传易感性的关系。方法以山东地区1 007例确诊的子痫前期病人为病例组,1 392例正常分娩的孕妇为对照组,采用TaqMan探针实时荧光PCR技术扩增两组外周血DNA,对GPx4基因的rs4807542位点进行基因分型和等位基因频率分析。结果病例组和对照组GPx4基因rs4807542位点的基因型分布和等位基因频率差异无统计学意义(P>0.05)。轻度及重度子痫前期组与对照组比较,早发型及晚发型子痫前期组与对照组比较,该位点的基因型分布和等位基因频率差异均无显著性(P>0.05)。结论 GPx4基因rs4807542位点的单核苷酸多态性与子痫前期遗传易感性无相关性。Objective To explore the relationship between single nucleotide polymorphism of rs4807542 in GPx4gene and hereditary susceptibility of preeclampsia. Methods This study consisted of 1 007 patients diagnosed as suffering from preeclampsia（case group）and 1 392 pregnant women with normal delivery（control group）.Applying TaqMan allelic discrimination real-time PCR technique,peripheral blood DNA in the two groups was amplified.Gene typing and allele frequency analysis of rs4807542 locus in GPx4 gene were conducted. Results The differences in genotypic distribution and allelic frequencies at rs4807542 sites between the case group and control group were not significant（P〉0.05）.There were also no significant differences in genetic distributions between mild/severe preeclampsia or early/late-onset preeclampsia and control subgroups（P〉0.05）.Conclusion There is no correlation between the polymorphism of rs4807542 and hereditary susceptibility in preeclampsia.

关 键 词：先兆子痫 谷胱甘肽过氧化酶 多态性 单核苷酸 疾病遗传易感性 

分 类 号：R714.244[医药卫生—妇产科学] R363.25[医药卫生—临床医学]