Protective effect of tetrahydroxy stilbene glucoside on learning and memory by regulating synaptic plasticity  

作　　者：Hong-bo Luo Yun Li Zun-jing Liu Li Cao Zhi-qiang Zhang Yong Wang Xiao-yan Zhang Zhao Liu Xiang-qun Shi 

机构地区：[1]Department of Neurology,Lanzhou General Hospital,Lanzhou Military Area Command [2]Department of Neurology,China-Japan Friendship Hospital

出　　处：《Neural Regeneration Research》2016年第9期1480-1486,共7页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81303097,81373794

摘　　要：Damage to synaptic plasticity induced by neurotoxicity of amyloid-beta is regarded to be one of the pathological mechanisms of learning and memory disabilities in Alzheimer＇s disease patients. This study assumed that the damage of amyloid-beta to learning and memory abilities was strongly associated with the changes in the Fyn/N-methyl-D-aspartate receptor 2B （NR2B） expression. An APP695V7171 transgenic mouse model of Alzheimer＇s disease was used and treatment with tetrahydroxy-stilbene glucoside was administered intragas- trically. Results showed that intragastric administration of tetrahydroxy-stilbene glucoside improved the learning and memory abilities of the transgenic mice through increasing NR2B receptors and Fyn expression. It also reversed parameters for synaptic interface structure of gray type I. These findings indicate that tetrahydroxy stilbene glucoside has protective effects on the brain, and has prospects for its clinical application to improve the learning and memory abilities and treat Alzheimer＇s disease.Damage to synaptic plasticity induced by neurotoxicity of amyloid-beta is regarded to be one of the pathological mechanisms of learning and memory disabilities in Alzheimer＇s disease patients. This study assumed that the damage of amyloid-beta to learning and memory abilities was strongly associated with the changes in the Fyn/N-methyl-D-aspartate receptor 2B （NR2B） expression. An APP695V7171 transgenic mouse model of Alzheimer＇s disease was used and treatment with tetrahydroxy-stilbene glucoside was administered intragas- trically. Results showed that intragastric administration of tetrahydroxy-stilbene glucoside improved the learning and memory abilities of the transgenic mice through increasing NR2B receptors and Fyn expression. It also reversed parameters for synaptic interface structure of gray type I. These findings indicate that tetrahydroxy stilbene glucoside has protective effects on the brain, and has prospects for its clinical application to improve the learning and memory abilities and treat Alzheimer＇s disease.

关 键 词：nerve regeneration tetrahydroxy stilbene glucoside AIzheimer＇s disease AMYLOID-BETA cognitive impairment learning and memory synaptic plasticity Fyn/N-methyl-D-aspartate receptor 2B signaling pathway NEUROPROTECTION neural regeneration 

分 类 号：R749.16[医药卫生—神经病学与精神病学]