微生物发酵法生产灵菌红素研究进展  

Progress in microbial production of prodigiosin

作　　者：尤忠毓 王玉洁[1] 孙诗清[1] 刘晓侠[1] Zhongyu You Yujie Wang Shiqing Sun Xiaoxia Liu(College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, China)

机构地区：[1]嘉兴学院生物与化学工程学院,浙江嘉兴314001

出　　处：《生物工程学报》2016年第10期1332-1347,共16页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(No.31100053);浙江省自然科学基金(No.LQ14C050002);浙江省公益性技术应用研究计划项目(No.2014C31046);浙江省纱线材料成型与复合加工技术研究重点实验室开放项目(No.MTC2014-007);嘉兴市科技项目(No.2014BY15001)资助~~

摘　　要：灵菌红素是一种微生物次级代谢产生的重要天然红色素,在医药开发、环境治理和染料制备等领域具有巨大的潜在应用价值。文中从3个方面归纳了国内外关于灵菌红素的研究进展:产灵菌红素微生物的发现与改造;灵菌红素发酵与提取过程的控制与优化;灵菌红素生物合成途径及其转录调控机制的解析。最后,讨论了微生物发酵法生产灵菌红素今后的研究方向。Prodigiosin is an important natural red pigment that is produced as a secondary metabolite by microorganisms,and has great potential applications in the field of pharmaceutical development,environmental management and dye preparation.This paper reviews recent research progress in the production of prodigiosin by microbial fermentation,including discovery and modification of the prodigiosin-producing microorganisms,regulation and optimization of prodigiosin fermentation and extraction process,and resolution of biosynthetic pathway of prodigiosin and related transcriptional regulation.Finally,we discussed the future research directions in microbial production of prodigiosin.

关 键 词：灵菌红素 发酵生产 菌株选育 优化控制 合成途径 转录调控 

分 类 号：TQ920.6[轻工技术与工程—发酵工程]