Properties and feasibility of using cancer stem cells in clinical cancer treatment  

作　　者：Xiao-Mei Gao Rui Zhang Qiong-Zhu Dong Lun-Xiu Qin 

机构地区：[1]Institutes of Biomedical Sciences, Fudan University [2]Department of General Surgery, Huashan Hospital and Cancer Metastasis Institute, Fudan University

出　　处：《Cancer Biology & Medicine》2016年第4期489-495,共7页癌症生物学与医学（英文版）

基　　金：supported by the grants from the National Key Basic Research Program of China (Grant No. 2013CB910500);China National Key Projects for Infectious Disease (Grant No. 2012ZX10002-012);National Natural Science Foundation of China (Grant No. 81372647)

摘　　要：Cancer treatment failure, drug resistance, or metastatic recurrence are thought to be caused mainly by the existence of a very small number of cancer stem cells(CSCs). The characteristics of this subgroup of cells include self-renewal, tumorigenesis, multiple differentiation and high invasiveness, metastasis, and drug resistance potential. Many studies have demonstrated that CSCs play important roles in tumor growth, spread and metastatic relapse after treatment, and are closely related to the prognosis of patients.From a therapeutic viewpoint, deep insights into the CSCs biology, development of specific therapeutic strategies for targeting CSCs, and characterization of their microenvironment could be an ideal way to combat cancer.Cancer treatment failure, drug resistance, or metastatic recurrence are thought to be caused mainly by the existence of a very small number of cancer stem cells（CSCs）. The characteristics of this subgroup of cells include self-renewal, tumorigenesis, multiple differentiation and high invasiveness, metastasis, and drug resistance potential. Many studies have demonstrated that CSCs play important roles in tumor growth, spread and metastatic relapse after treatment, and are closely related to the prognosis of patients.From a therapeutic viewpoint, deep insights into the CSCs biology, development of specific therapeutic strategies for targeting CSCs, and characterization of their microenvironment could be an ideal way to combat cancer.

关 键 词：Cancer stem cells CANCERS treatment failure METASTASIS cancer therapy 

分 类 号：R730.5[医药卫生—肿瘤]