一种新的RNA二级结构三维图形表示及其应用  

A new 3-D graphical representation of RNA secondary structure and its application

作　　者：刘立伟[1] 刘铁晖 LIU Liwei LIU Tiehui(Dalianjiaotong university school of science, Dalian Liaoning 116028, China)

机构地区：[1]大连交通大学理学院,辽宁大连116028

出　　处：《生物信息学》2017年第1期55-58,共4页Chinese Journal of Bioinformatics

基　　金：辽宁省教育厅科学研究一般项目(No.L 2015093)

摘　　要：本研究提出了一种新的RNA二级结构的图形表示方法,这种方法不同于以往的表示方式。根据所提出的RNA二级结构的图形表示,将对9种病毒的RNA二级结构进行图形表示,构建系统进化树,进行序列间相似性的比较和分析。根据最终结果,可以很清晰地发现,AVII与LRMV两种病毒是最为相似的,另外,较大的距离值出现在了APMV与ALMV;PDV与AVII中,这说明这几种RNA二级结构明显不相似。这一研究结果与前人相似性分析的结果是十分相似的,同时,所采取的方法更加简单易于区分观察且得到的结果又是十分可靠的,因此,这些更加证明了该方法是有效的。Recently, we propose a new 3D graphical representation of RNA secondary structures. Based on this graph representation, we will construct the phylogenetic tree of the 9 viruses, and compare and analyze the similarity between the RNA secondary structures.According to the final results, we clearly find that Pair AVII and LRMV are the most similar. In addition, the larger distance values appear in the APMV and ALMV, PDV and AVII, indicating that these RNA secondary structure sequence has obvious difference. The results of this study are very similar to previous published results one. At the same time, the used method is more simple and easy to identify what we see, while the results is very reliable. Therefore, these results demonstrate the effectivity of our methed.

关 键 词：RNA二级结构 图形表示 系统进化树 相似性 

分 类 号：Q522[生物学—生物化学]