Turner综合征患儿甲状腺自身抗体的变化及其与血脂异常的关系  

Changes of thyroid autoantibodies and its relationship with dyslipidaemia in children with Turner syndrome

作　　者：劳文芹 孟哲[2] 欧辉[2] 张丽娜[2] 侯乐乐[2] 刘祖霖[2] 江转南 梁立阳[2] 

机构地区：[1]广州医科大学附属第二医院儿科,510260 [2]中山大学孙逸仙纪念医院儿科,广州510120

出　　处：《中华实用儿科临床杂志》2017年第8期579-581,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：目的 了解Turner综合征（TS）患儿自身免疫性甲状腺抗体（TAA）的变化特点及其与甲状腺功能、年龄、核型、血脂代谢异常的关系。方法 收集2007年7月至2015年7月中山大学孙逸仙纪念医院32例经染色体核型分析确诊的TS患儿临床资料，检测血清TAA，将患儿分为TAA阳性组与TAA阴性组，对2组患儿的甲状腺功能、年龄、染色体核型和血脂情况进行对比分析。结果 TAA阳性患儿23例（23/32例，71.88%），其中甲状腺功能异常9例（9/23例，39.13%）；TAA阴性患儿9例（9/32例，28.12%），其中甲状腺功能异常3例（3/9例，33.33%）。TAA阳性组与TAA阴性组年龄分别为（12.08±2.90）岁和（8.89±4.17）岁，2组间比较差异有统计学意义（t＝101.500，P＝0.047）。按年龄分为0～5岁、〉5～10岁、〉10～15岁和〉15岁4组，各年龄组TAA阳性率分别为25.00%（1/4例）、75.00%（6/8例）、82.35%（14/17例）和66.67%（2/3例）。32例TS患儿检测脂代谢20例，出现脂代谢紊乱者11例（11/20例，55.00%），其中TAA阳性患儿9例（81.82%），TAA阴性患儿2例（18.18%），2组脂代谢紊乱发病率比较差异有统计学意义（χ2＝4.848，P＝0.028）；TS各种核型之间与TAA阳性率差异无统计学意义（χ2＝4.246，P＝0.120）。结论 TS合并TAA阳性患儿易出现甲状腺功能异常及脂代谢紊乱，应定期监测TAA及甲状腺功能，必要时随诊脂代谢相关检查。Objective To investigate the changes of thyroid autoantibody （TAA） in children with Turner syndrome（TS）, and its association between TAA and thyroid dysfunction, age, karyotype and dyslipidaemia.Methods Thirty-two patients with TS diagnosed by chromosome analysis hospitalized at Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University from July 2007 to July 2015 were divided into 2 groups based on TAA-positive or TAA-negative, then the thyroid dysfunction, the age, the karyotype and the lipid metabolism were compared between 2 groups.Results Of the 23 cases of TAA-positive girls（23/32 cases, 71.88%）, 9 girls（39.13%） suffered from thyroid dysfunction; of the 9 cases of TAA-negative girls （9/32 cases, 28.12%）, 3 girls（33.33%） had thyroid dysfunction.As compared with the girls in TAA-negative group, the age in TAA-positive group was significantly higher[（12.08±2.90） years old vs.（8.89±4.17）years old], and the difference was significant（t=101.500, P=0.047）. The patients were divided into 4 age groups： 0-5 years old, 〉5-10 years old, 〉10-15 years old and 〉15 years old; the rates with TAA-positive were 25.00% （1/4 cases）, 75.00%（6/8 cases）, 82.35% （14/17 cases） and 66.67%（2/3 cases） respectively.Twenty patients received the lipid metabolism test, and 11 cases（11/20 cases, 55.00%） of them suffered from dyslipidaemia, 9 cases of them were TAA-positive （9/11 cases, 81.82%）, and 2 cases were TAA-negative（2/11 cases, 18.18%）. The differences in the prevalence of dyslipidaemia between the 2 groups were significant （χ2=4.848, P=0.028）. There was no significant difference in the numbers of TAA-positive cases among different karyotypes（χ2 =4.246, P=0.120）.Conclusions Patients with TS are prone to suffer from thyroid dysfunction and dyslipidaemia.Timely detection of TAA and thyroid function is recommended, as well as the lipid metabolism if necessary.

关 键 词：TURNER综合征 甲状腺抗体 血脂异常 

分 类 号：R725.9[医药卫生—儿科]