响应面法优化月桂酸单甘油酯的催化合成工艺  

Optimization of catalytic synthesis of glycerol monolaurate using response surface methodology

作　　者：周军[1] 李湘洲[1,2] 徐雷涛[1] 熊曼[1] 郭颂[1] 

机构地区：[1]中南林业科技大学材料科学与工程学院 [2]南方林业生态应用技术国家工程实验室,长沙410004

出　　处：《中国食品添加剂》2017年第4期67-73,共7页China Food Additives

基　　金：国家林业公益性行业科研专项(201204811)

摘　　要：以月桂酸和甘油为原料,采用直接酯化法合成月桂酸单甘油酯,单因素试验考察了催化剂种类与用量、反应时间、反应温度和物料摩尔比对合成产物中月桂酸单甘油酯含量的影响。在此基础上,利用响应面法对合成工艺进行优化,获得响应面优化工艺为:以氧化钙为催化剂,其用量0.21%,反应时间5.4 h,反应温度166℃,甘油与月桂酸的摩尔比1.5︰1,此条件下产物中月桂酸单甘油酯的含量为61.81%。以正己烷为溶剂,在低温下经三次结晶后获得含量为93.64%的纯化产物,红外光谱分析表明,溶剂结晶纯化效果明显。Glycerol monolaurate（GML）was synthesized by esterification method using lauric acid and glycerol.Five factors such as catalyst types and dosage,reaction time,reaction temperature and mole ratio of material were studied.The snthesis process was optimized by using response surface method.The optimized process was：0.21% calcium oxide as the catalyst,reaction time 5.4 h,reaction temperature 166℃,the molar ratio of glycerol and lauric acid 1.5 ∶ 1,GML content of products was 61.81% under the above condition.The content of purification products was 93.64% after three times crystallization at low temperature using n-hexane as the solvent.Infrared spectrum analysis showed that solvent crystallization was obvious.

关 键 词：月桂酸单甘油酯 响应面法 溶剂结晶法 含量 红外光谱分析 

分 类 号：TS202.3[轻工技术与工程—食品科学]