A review on Eph/ephrin,angiogenesis and lymphangiogenesis in gastric,colorectal and pancreatic cancers  

作　　者：Julia Rudno-Rudzifiskal Wojciech Kielan Ewelina Frejlichl Krzysztof Kotulski Wojciech Hap Krzysztof Kurnoll Przemystaw Dzierzek Marcin Zawadzkil, Agnieszka Haton julia rudno-rudzińska;wojciech kielan;ewelina frejlich;krzysztof kotulski;wojciech hap;krzysztof kurnol;przemyslaw dzierzek;marcin zawadzki;agnieszka haloń(2-nd department of general and oncological surgery,wroclaw medical university,Borowska 213,50-556 Wrodaw,Poland;pathology department,wroclaw medical university,Borowska 213,50-556 Wrodaw,Poland)

机构地区：[1]-nd Department of General and Oncological Surgery [2]pathology Department, Wrodaw Medical University, Borowska 213, 50-556 Wrochw Poland

出　　处：《Chinese Journal of Cancer Research》2017年第4期303-312,共10页中国癌症研究（英文版）

摘　　要：Erythroprotein-producing human hepatocellular carcinoma receptors （Eph receptors） compose a subfamily of transmembrane protein-tyrosine kinases receptors that takes part in numerous physiological and pathological processes. Eph family receptor-interacting proteins （Ephrins） are ligands for those receptors. Eph/ephrin system is responsible for the cytoskeleton activity, cell adhesion, intercellular connection, cellular shape as well as cell motility. It affects neuron development and functioning, bone and glucose homeostasis, immune system and correct function of enterocytes. Moreover Eph/ephrin system is one of the crucial ones in angiogenesis and lymphangJogenesis. With such a wide range of impact it is clear that disturbed function of this system leads to pathology. Eph/ephrin system is involved in carcinogenesis and cancer progression. Although the idea of participation of ephrin in carcinogenesis is obvious, the exact way remains unclear because of complex bi-directional signaling and cross-talks with other pathways. Further studies are necessary to find a new target for treatment.Erythroprotein-producing human hepatocellular carcinoma receptors （Eph receptors） compose a subfamily of transmembrane protein-tyrosine kinases receptors that takes part in numerous physiological and pathological processes. Eph family receptor-interacting proteins （Ephrins） are ligands for those receptors. Eph/ephrin system is responsible for the cytoskeleton activity, cell adhesion, intercellular connection, cellular shape as well as cell motility. It affects neuron development and functioning, bone and glucose homeostasis, immune system and correct function of enterocytes. Moreover Eph/ephrin system is one of the crucial ones in angiogenesis and lymphangJogenesis. With such a wide range of impact it is clear that disturbed function of this system leads to pathology. Eph/ephrin system is involved in carcinogenesis and cancer progression. Although the idea of participation of ephrin in carcinogenesis is obvious, the exact way remains unclear because of complex bi-directional signaling and cross-talks with other pathways. Further studies are necessary to find a new target for treatment.

关 键 词：Epldephrin system LYMPHANGIOGENESIS ANGIOGENESIS gastric cancer colon cancer pancreatic cancer 

分 类 号：R735[医药卫生—肿瘤]