New diterpenoids isolated from Leonurus japonicus and their acetylcholinesterase inhibitory activity  

作　　者：WU Han-Kui SUN Ting ZHAO Feng ZHANG Li-Ping LI Gang ZHANG Jie 

机构地区：[1]College of Chemistry and Chemical Engineering, Anyang Normal University [2]Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University

出　　处：《Chinese Journal of Natural Medicines》2017年第11期860-864,共5页中国天然药物（英文版）

基　　金：supported by the National Na ural Science Foundation of China(Nos.:U1304301,U1304825,an201302004)

摘　　要：Three new labdane diterpenoids, leojaponicone A(1), isoleojaponicone A(2) and methylisoleojaponicone A(3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1 D and 2 D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 exhibited low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A.Three new labdane diterpenoids, leojaponicone A（1）, isoleojaponicone A（2） and methylisoleojaponicone A（3）, were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1 D and 2 D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 exhibited low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A.

关 键 词：Leonurus JAPONICUS Leojaponicone ACETYLCHOLINESTERASE LABDANE DITERPENOID 

分 类 号：R284.1[医药卫生—中药学] R965[医药卫生—中医学]