Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer's disease  

作　　者：MA Wei-Wei TAO Ye WANG Yan-Ying PENG I-Feng 

机构地区：[1]School of Life Science, Tsinghua University, Beijing 100084, China [2]Suzhou Joekai Biotech LLC, Kunshan City, Jiangsu, 215300, China

出　　处：《Chinese Journal of Natural Medicines》2017年第12期899-904,共6页中国天然药物（英文版）

基　　金：supported by programs of Thousand Talents Program Research Park(Jiangsu,China);Provincial Innovation and Entrepreneurial Talent,Jiangsu,China(to I.F.P,);Development of Society and Technology(Kunshan City,Jiangsu,China)

摘　　要：Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer's disease(AD) model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng(GPP) also support its therapeutic effects on memory improvement. Interestingly, the application of GPP and gardenoside did not alter the accumulation of Abeta proteins but suppressed the expression of immune-related genes in the brain. These results revealed the importance and relevancy of anti-inflammation process and the underlying mechanisms on rescuing memory deficits, suggesting the potential therapeutic use of the improved GPP formulation in improving cognition in defined population in the future.Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer＇s disease（AD） model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng（GPP） also support its therapeutic effects on memory improvement. Interestingly, the application of GPP and gardenoside did not alter the accumulation of Abeta proteins but suppressed the expression of immune-related genes in the brain. These results revealed the importance and relevancy of anti-inflammation process and the underlying mechanisms on rescuing memory deficits, suggesting the potential therapeutic use of the improved GPP formulation in improving cognition in defined population in the future.

关 键 词：Gardenoside GENIPOSIDE CROCIN Inflammation Memory GARDENIA jasminoides NEURODEGENERATIVE diseases 

分 类 号：R965[医药卫生—药理学]