脑卒中lncRNA与mRNA表达谱分析  

The Analysis of LncRNA and MRNA Gene Expression Profiles in Stroke

作　　者：王玺 王凡 宁浩宇 白雪峰[1] WANG Xi;WANG Fan;NING Hao-yu;BAI Xue-feng(Department of Medical lnformatics, Daqing Campus, Harbin Medical University, Daqing, Heilongjiang, 163319)

机构地区：[1]哈尔滨医科大学大庆校区医学信息学院,黑龙江大庆163319

出　　处：《智慧健康》2018年第7期5-8,共4页Smart Healthcare

基　　金：黑龙江省大学生创新创业训练计划项目(重点项目)(编号:201610226015)

摘　　要：本文研究差异表达的lncRNAs、mRNAs在脑卒中疾病中的调控机理。对脑卒中表达谱进行分析,建立了lncRNA-mRNA疾病网络,利用cytoscape发现了五个与疾病相关的重要模块。对五个模块进行功能注释,发现多个模块中出现重复的功能注释,其中代谢相关功能在多个模块重复出现,与脑卒代谢中密切相关;多个模块注释到转录调控功能,表明基因通过协同作用行使功能调控脑卒中,通过本文的研究得到lncRNAs与mRNAs协同作用的一些结果,为临床治疗研究提供科学的理论依据。In this paper, we study the regulatory mechanism of differentially expressed lncRNAs and mRNAs in stroke. we analyzed the expression profiles of stroke and set up the lncRNAs-mRNA disease network. We obtained five significant functional modules by cycoscape. We annotated the five modules and find their functions associated to metabolism repeated in multiple modules, it indicated that metabolism was closely related to stroke. Multiple modules are annotated with transcriptional regulatory functions, suggesting that genes play a synergistic role in the regulation of stroke. Furthermore,the synergy results of lncRNAs-mRNAs are obtained in the paper, these could be provide scientific theoretical basis for clinical treatment.

关 键 词：脑卒中 lncRNAs MRNAS 功能注释 

分 类 号：R743.3[医药卫生—神经病学与精神病学]