Neuroplasticity, limbic neuroblastosis and neuro-regenerative disorders  

作　　者：Mahesh Kandasamy Ludwig Aigner 

机构地区：[1]Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University [2]Faculty Recharge Programme, University Grants Commission (UGC-FRP) [3]Institute of Molecular Regenerative Medicine, Salzburg, Paracelsus Medical University [4]Spinal Cord Injury and Tissue Regeneration Center, Salzburg, Paracelsus Medical University

出　　处：《Neural Regeneration Research》2018年第8期1322-1326,共5页中国神经再生研究（英文版）

基　　金：supported by the FWF Special Research Program(SFB)F44(F4413-B23)"Cell Signaling in Chronic CNS Disorders",and through funding from the European Union’s Seventh Framework Program(FP7/2007-2013)under grant agreements n°HEALTH-F2-2011-278850(INMi ND),n°HEALTH-F2-2011-279288(IDEA),n°FP7-REGPOT-316120(Glow Brain);a startup grant from the Faculty Recharge Programme,University Grants Commission(UGC-FRP),New Delhi,India(to MK);a research grant from DST-SERB,New Delhi,India(EEQ/2016/000639)(to MK);an Early Career Research Award(ECR/2016/000741)(to MK)

摘　　要：The brain is a dynamic organ of the biological renaissance due to the existence of neuroplasticity. Adult neurogenesis abides by every aspect of neuroplasticity in the intact brain and contributes to neural regeneration in response to brain diseases and injury. The occurrence of adult neurogenesis has unequivocally been witnessed in human subjects, experimental and wildlife research including rodents, bats and cetaceans. Adult neurogenesis is a complex cellular process, in which generation of neuroblasts namely, neuroblastosis appears to be an integral process that occur in the limbic system and basal ganglia in addition to the canonical neurogenic niches. Neuroblastosis can be regulated by various factors and contributes to different functions of the brain. The characteristics and fate of neuroblasts have been found to be different among mammals regardless of their cognitive functions. Recently, regulation of neuroblastosis has been proposed for the sensorimotor interface and regenerative neuroplasticity of the adult brain. Hence, the understanding of adult neurogenesis at the functional level of neuroblasts requires a great scientific attention. Therefore, this mini-review provides a glimpse into the conceptual development of neuroplasticity, discusses the possible role of different types of neuroblasts and signifies neuroregenerative failure as a potential cause of dementia.The brain is a dynamic organ of the biological renaissance due to the existence of neuroplasticity. Adult neurogenesis abides by every aspect of neuroplasticity in the intact brain and contributes to neural regeneration in response to brain diseases and injury. The occurrence of adult neurogenesis has unequivocally been witnessed in human subjects, experimental and wildlife research including rodents, bats and cetaceans. Adult neurogenesis is a complex cellular process, in which generation of neuroblasts namely, neuroblastosis appears to be an integral process that occur in the limbic system and basal ganglia in addition to the canonical neurogenic niches. Neuroblastosis can be regulated by various factors and contributes to different functions of the brain. The characteristics and fate of neuroblasts have been found to be different among mammals regardless of their cognitive functions. Recently, regulation of neuroblastosis has been proposed for the sensorimotor interface and regenerative neuroplasticity of the adult brain. Hence, the understanding of adult neurogenesis at the functional level of neuroblasts requires a great scientific attention. Therefore, this mini-review provides a glimpse into the conceptual development of neuroplasticity, discusses the possible role of different types of neuroblasts and signifies neuroregenerative failure as a potential cause of dementia.

关 键 词：NEUROPLASTICITY adult neurogenesis NEUROBLASTS reactive neuroblastosis hippocampus ultrasound neuroregenerative disorders neotrophy ECHOLOCATION 

分 类 号：R739.4[医药卫生—肿瘤] R741[医药卫生—临床医学]