supported by grants from Consellería de Cultura,Educación e Ordenación Universitaria,Xunta de Galicia(ED431G/05,ED431C 2018/10);European Regional Development Fund(FEDER),Instituto de Salud CarlosⅢ(RD16/011/0016,RD21/0017/0031);Secretaría de Estado de Investigación,Desarrollo e Innovación(Grant/Award,number RTI2018-098830-B-I00)(to JLLG)。
Parkinson’s disease is a neurodegenerative condition characterized by motor impairments caused by the selective loss of dopaminergic neurons in the substantia nigra.Levodopa is an effective and well-tolerated dopamin...
The binding properties of neural cell adhesion molecule are modulated by a polysialic acid moiety. This plays an important role in the migration of adult born neuroblasts from their area of origin, the subventricular ...
supported by the FWF Special Research Program(SFB)F44(F4413-B23)"Cell Signaling in Chronic CNS Disorders",and through funding from the European Union’s Seventh Framework Program(FP7/2007-2013)under grant agreements n°HEALTH-F2-2011-278850(INMi ND),n°HEALTH-F2-2011-279288(IDEA),n°FP7-REGPOT-316120(Glow Brain);a startup grant from the Faculty Recharge Programme,University Grants Commission(UGC-FRP),New Delhi,India(to MK);a research grant from DST-SERB,New Delhi,India(EEQ/2016/000639)(to MK);an Early Career Research Award(ECR/2016/000741)(to MK)
The brain is a dynamic organ of the biological renaissance due to the existence of neuroplasticity. Adult neurogenesis abides by every aspect of neuroplasticity in the intact brain and contributes to neural regenerati...
supported by the National Basic Research Program of China (No.2013CB945600);the National Natural Science Foundation of China (No.31371381)
In the Drosophila larval brain, type I and type Ⅱ neuroblasts(NBs) undergo a series of asymmetric divisions which give rise to distinct progeny lineages. The intermediate neural progenitors(INPs) exist only in ty...
supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education,No.NRF-2013R1A1A2059364,NRF-2015R1D1A3A01020635);by 2013 Research Grant from Kangwon National University;partially supported by the Research Institute for Veterinary Science,Seoul National University
Recent evidence exists that glucose transporter 3(GLUT3) plays an important role in the energy metabolism in the brain.Most previous studies have been conducted using focal or hypoxic ischemia models and have focuse...
Similarly to other adult tissues,a hierarchical structure has been established for the brain,where the differentiated cell types(neurons,oligodendrocytes and astrocytes)are generated from primary progenitor cells,kn...
supported by the Hunan Provincial Innovation Foundation for Postgraduate in China,No.CX2014B099(to XH);the Science Foundation of Hunan Provincial Education Department of China,No.11C1264(to FJD),13C958(to XH)
The main active components extracted from Panax notoginseng are total saponins. They have been shown to inhibit platelet aggregation, increase cerebral blood flow, improve neurological behavior, decrease infarct volum...
It has long been thought that neu- rogenesis (birth of neurons) in the mammalian brain only occurs while the central nervous system is still develop- ing. Although the first indications to the contrary already appea...
This work was supported by the National Natural Science Foundation of China(30870804,30900425,30970949,30990261,30821002 and 31028009);Shanghai Shu-Guang project(09SG05);National Basic Research Program of China(2010CB945500,2011CB504400).
It is of great interest to identify new neurons in the adult human brain,but the persistence of neurogenesis in the subventricular zone(SVZ)and the existence of the rostral migratory stream(RMS)-like pathway in the ad...
DNA damage can, but does not always, induce cell death. While several pathways linking DNA damage signals to mitochondria-dependent and -independent death machineries have been elucidated, the connectivity of these pa...