无抽搐电休克治疗对精神分裂症患者短时及瞬间记忆的影响  

Effects of modified electroconvulsive therapy on immediate memory and short-term memory of schizophrenic patients

作　　者：陶领钢 李启斌 于海[1] 石顺治 刘训 TAO Ling-gang;L;YU Hai;SHI Shun-zhi;LIU Xun(Guilin Mental Health Center,Guilin 541 O01,China;Department of Mental Hygiene,Guilin Medical University,Guilin 541 001,China)

机构地区：[1]广西桂林市精神卫生中心,桂林市541001 [2]桂林医学院精神心理卫生学教研室,广西桂林市541001

出　　处：《广西医学》2018年第13期1427-1430,共4页Guangxi Medical Journal

基　　金：广西医药卫生科研课题(Z2010207)

摘　　要：目的观察无抽搐电休克治疗(MECT)对精神分裂症患者的短时记忆及瞬间记忆的影响。方法将80例急性发作期的精神分裂症患者,随机分为研究组和对照组,每组40例,两组均给予利培酮口服,研究组加用MECT治疗,疗程均为8周。分别于治疗前、治疗后4周末、8周末采用阳性和阴性症状量表(PANSS)评定其病情;治疗前后采用韦氏记忆量表(WMS)评价患者的短时记忆和瞬时记忆(再认、图片、联想、背数四项因子)。结果研究组治疗总有效率为87.5%(35/40),对照组为62.5%(25/40),研究组疗效优于对照组(P<0.001)。研究组患者PANSS量表的阳性因子、阴性因子、一般精神病理量表因子、攻击因子得分和总分均低于对照组(均P<0.05)。治疗后,两组WMS的再认、图片、联想、背数因子得分及总分均高于治疗前(均P<0.05),并且研究组再认因子得分差值高于对照组(P<0.001),但治疗后两组图片、联想、背数因子得分差值比较,差异无统计学意义(均P>0.05)。结论 MECT联合利培酮治疗急性期发作精神分裂症疗效好,安全性高,且对患者的短时及瞬间记忆无明显影响。Objective To observe the effects of modified electroconvulsive therapy（ MECT） on the immediate and short-term memory of schizophrenic patient. Methods Eighty patients with acute attack of schizophrenia were randomly divided into study group and control group,with 40 cases in each group. Both groups were given oral risperidone,and the study group received MECT additionally. All cases were treated for 8 weeks. The Positive and Negative Symptom Scale（ PANSS） was used to assess the severity of the disease at the following time points,before treatment,4 weeks after treatment and 8 weeks after treatment. Before and after treatment,the Wechsler Memory Scale（ WMS） was used to evaluate the short-term and immediate memory of the patients,including 4 factors of recognition,picture,association and reciting numbers. Results The total effective rates of the study group and control group were 87. 5%（ 35/40） and 62. 5%（ 25/40）respectively,and the efficacy of the study group was better than that of the control group（ P〈0. 001）. The scores of PANSS items,including positive factor,negative factor,factors of general psychopathological scale,and attack factor,as well as the total score in the study group were all lower than those in the control group（ all P〈0. 05）. After treatment,the scores of WMS items,including recognition,picture,association and reciting numbers factor,as well as the total score were higher in both groups compared to the scores before treatment（ all P〈0. 05）,and the score difference of recognition factor in the study group was higher than that in the control group（ P〈0. 001）,however,there was no significant difference between the two groups in the score difference of picture,association or reciting numbers factor（ all P〈0. 05）.Conclusion MECT combined with risperidone has no significant effects on the short-term or immediate memory of patients with acute attack of schizophrenia,achieving a favorable efficacy and high safety.

关 键 词：精神分裂症 无抽搐电休克治疗 短时记忆 瞬时记忆 

分 类 号：R749.3[医药卫生—神经病学与精神病学]