Two new C_(21) steroidal glycosides isolated from Cynanchum komarovii  

作　　者：ZHAO Dan SU Shan-Shan CHEN Shao-Fei LU Xiao-Jie CHEN Gang WANG Yu-Bo SU Guang-Yue PEI Yue-Hu 

机构地区：[1]Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,Shenyang Pharmaceutical University [2]School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University [3]Testing Laboratory,Qinghai Entry Exit Inspection and Quarantine Bureau [4]School of Pharmacy,Jinzhou Medical University

出　　处：《Chinese Journal of Natural Medicines》2018年第8期610-614,共5页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.31370375)

摘　　要：The present study was designed to further investigate the C_(21) steroidal glycosides in Cynanchum plants.Two new steroidal glycosides based on a 13,14:14,15-disecopregnane-type aglycone,komaroside P(1) and komaroside Q(2),together with three known compounds(3-5) were isolated from the whole herbs of Cynanchum komarovii.The aglycones of compounds 1 and 2 were two new disecopregnane.Their structures were elucidated on the basis of 1 D,2 D NMR spectroscopic data and acid hydrolysis.All the compounds(1-5) showed potent inhibitory activities against human leukemia cell lines(HL-60) with IC50 values ranging from 16.6 to 26.3 μmol·L^(-1),compared to the positive control 5-fluorouracil(6.4 μmol·L^(-1)).The present study was designed to further investigate the C21 steroidal glycosides in Cynanchum plants.Two new steroidal glycosides based on a 13,14：14,15-disecopregnane-type aglycone,komaroside P（1） and komaroside Q（2）,together with three known compounds（3-5） were isolated from the whole herbs of Cynanchum komarovii.The aglycones of compounds 1 and 2 were two new disecopregnane.Their structures were elucidated on the basis of 1 D,2 D NMR spectroscopic data and acid hydrolysis.All the compounds（1-5） showed potent inhibitory activities against human leukemia cell lines（HL-60） with IC50 values ranging from 16.6 to 26.3 μmol·L^（-1）,compared to the positive control 5-fluorouracil（6.4 μmol·L^（-1））.

关 键 词：CYNANCHUM komarovii C21 steroidal GLYCOSIDES CYTOTOXIC ACTIVITY 

分 类 号：R284.1[医药卫生—中药学]