Catalytic asymmetric brominative dearomatization reaction of benzofurans  

作　　者：Xiao-Wei Liang Xiaoling Chen Zhiguo Zhang Shu-Li You 

机构地区：[1]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences [2]Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University

出　　处：《Chinese Chemical Letters》2018年第8期1212-1214,共3页中国化学快报（英文版）

基　　金：the National Key R&D Program of China (No. 2016YFA0202900);National Basic Research Program of China (No.2015CB856600);the National Natural Science Foundation of China (Nos. 21332009, 21421091);the Chinese Academy of Sciences (Nos. XDB20000000, QYZDY-SSW-SLH012) for generous financial support

摘　　要：A catalytic asymmetric brominative dearomatization reaction of benzofuran derivatives was achieved by using hydroquinidine 1,4-phthalazinediyl diether [（DHQ）_2PHAL] as the catalyst and N-bromoacetamide（NBAc） as the brominating reagent. A series of brominated spiro[benzofuran-2,5＇-oxazoles] bearing two contiguous stereogenic centers were obtained in high yields（up to 99%） with excellent enantioselectivity（up to 97% ee）.A catalytic asymmetric brominative dearomatization reaction of benzofuran derivatives was achieved by using hydroquinidine 1,4-phthalazinediyl diether [（DHQ）_2PHAL] as the catalyst and N-bromoacetamide（NBAc） as the brominating reagent. A series of brominated spiro[benzofuran-2,5＇-oxazoles] bearing two contiguous stereogenic centers were obtained in high yields（up to 99%） with excellent enantioselectivity（up to 97% ee）.

关 键 词：Asymmetric catalysis BROMINATION BENZOFURAN DEAROMATIZATION ORGANOCATALYSIS 

分 类 号：O621.251[理学—有机化学]