Wnt／β-catenin信号转导通路对骨形成和骨肿瘤的调控作用  

Regulation of Wnt β-catenin signaling in bone development and bone tumor

作　　者：周振华[1] 肖建如[1] Zhou Zhenhua;XiaoJianru(Department of Orthopaedic Oneology,Changzheng Hospital,the Second Military Medical University,Shanghai 200003,China)

机构地区：[1]第二军医大学附属长征医院骨肿瘤,上海200003

出　　处：《中华外科杂志》2018年第10期797-800,共4页Chinese Journal of Surgery

基　　金：国家自然科学基金（81772857）

摘　　要：Wnt／β-catenin信号转导通路是影响骨发育的关键信号转导通路之一。正常情况下Wnt／β-catenin信号维持骨微环境处于稳态平衡，对骨髓间充质于细胞分化、破骨细胞的形成及骨量调节有重要调控作用。而该通路异常可能导致骨肿瘤、代谢性骨病、退行性骨病等各种相关疾病的发生，与骨肉瘤，尤因肉瘤等肿瘤的发生和转移密切相关。对Wnt／β-catenin信号转导通路的研究，为相关的分子靶向药物治疗骨病提供了理论基础。The Wnt/β-catenin signaling pathway is crucial in bone development and homeostasis. Normally, it has been suggested to play a significant role in regulation of osteogenic differentiation of bone marrow mesenchymal stem cells, osteoclastogenesis and bone mineral density. Dysregulated Wnt/β-catenin signaling pathway is responsible for bone tumor, metabolic bone disease, degenerative bone disease and it related to development and invasion of osteosarcoma and Ewing＇ s sarcoma. Studies of the molecular mechanisms of Wnt/β-catenin signaling pathway provide theoretical basis of a potential target for bone diseases.

关 键 词：WNT蛋白质类 骨肿瘤 微环境 WNT/Β-CATENIN信号转导通路 

分 类 号：R738.1[医药卫生—肿瘤]