Adult stem cell-based apexogenesis  

作　　者：Yao Li Li-Hong Shu Ming Yan Wen-Yong Dai Jun-Jun Li Guang-Dong Zhang Jin-Hua Yu Yao Li;Li-Hong Shu;Ming Yan;Wen-Yong Dai;Jun-Jun Li;Guang-Dong Zhang;Jin-Hua Yu(Institute of Stomatology,Nanjing Medical University;Department of Stomatology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital;Department of Stomatology, Children’s Hospital of Changzhou;Endodontic Department,Dental School of Nanjing Medical University)

机构地区：[1]Institute of Stomatology,Nanjing Medical University,Nanjing 210029,Jiangsu Province,China）Yao Li（Department of Stomatology,Nanjing Integrated Tradi-tional Chinese and Western Medicine Hospital,Nanjing 210014,Jiangsu Province,China）Li-Hong Shu（Department of Stomatology,Children＇s Hospital of Changzhou,Changzhou 213003,Jiangsu Province,China）Ming Yan,Guang-Dong Zhang,Jin-Hua Yu,Endodontic（De-partment,Dental School of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China

出　　处：《World Journal of Methodology》2014年第2期99-108,共10页世界方法学杂志

基　　金：Supported by National Natural Science Foundation of China,No.81371144;Natural Science Foundation of Jiangsu Province,No.BK20131392;the Priority Academic Program Development of Jiangsu Higher Education Institutions PAPD,No.2011-137

摘　　要：Generally, the dental pulp needs to be removed when it is infected, and root canal therapy(RCT) is usually required in which infected dental pulp is replaced with inorganic materials(paste and gutta percha). This treatment approach ultimately brings about a dead tooth. However, pulp vitality is extremely important to the tooth itself, since it provides nutrition and acts as a biosensor to detect the potential pathogenic stimuli. Despite the reported clinical success rate, RCT-treated teeth are destined to be devitalized, brittle and susceptible to postoperative fracture. Recently, the advances and achievements in the field of stem cell biology and regenerative medicine have inspired novel biological approaches to apexogenesis in young patients suffer-ing from pulpitis or periapical periodontitis. This review mainly focuses on the benchtop and clinical regeneration of root apex mediated by adult stem cells. Moreover, current strategies for infected pulp therapy are also discussed here.

关 键 词：Apexogenesis DENTAL PULP STEM cell ODONTOBLAST TOOTH REGENERATION 

分 类 号：O1[理学—数学]