4-氨基吡啶治疗上视性眼球震颤后视觉-眼球运动功能的恢复  

4-Aminopyridine restores visual ocularmotor functionin upbeat nystagmus

作　　者：Glasauer S. Kalla R. Bttner U. 王晓琳 

机构地区：[1]Department of Neurology, Klinikum Grosshadern,Marchioninistrasse 23, 81377 Munich, Germany Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第7期32-32,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：The effect of the potassium channel blocker 4-aminopyridine(4-AP) on spontan eous upbeat nystagmus (UBN) was investigated with the search coil technique duri ng fixation in different gaze positions and smooth pursuit in a patient before a nd after ingestion of 10 mg 4-AP. UBN was reduced from 8.6 deg/s to 2.0 deg/s b y 4-AP causing subjective relief from distressing oscillopsia, and impaired upw ard smooth pursuit was restored(gains: before medication 0.38; after medication 0.86). In the dark, UBN was slightly stronger and not affected by 4-AP. We prop ose that 4-AP improved the function of cerebellar pathways that mediate gaze ho lding and smooth pursuit by intensifying the excitability of cerebellar Purkinje cells.The effect of the potassium channel blocker 4-aminopyridine(4-AP) on spontan eous upbeat nystagmus (UBN) was investigated with the search coil technique duri ng fixation in different gaze positions and smooth pursuit in a patient before a nd after ingestion of 10 mg 4-AP. UBN was reduced from 8.6 deg/s to 2.0 deg/s b y 4-AP causing subjective relief from distressing oscillopsia, and impaired upw ard smooth pursuit was restored(gains: before medication 0.38; after medication 0.86). In the dark, UBN was slightly stronger and not affected by 4-AP. We prop ose that 4-AP improved the function of cerebellar pathways that mediate gaze ho lding and smooth pursuit by intensifying the excitability of cerebellar Purkinje cells.

关 键 词：眼球震颤 眼球运动 上视 钾通道阻断剂 浦肯野细胞 pursuit medication CEREBELLAR impaired BLOCKER 

分 类 号：R777.46[医药卫生—眼科]