唐氏综合征产前筛查1198例分析  

Analysis of 1198 Cases Down's Syndrome Prenatal Screening

作　　者：宋淑本[1] 廖灿[1] 魏佳雪[1] 易翠兴[1] 钟燕芳[1] 潘敏[1] 龚惠芳[1] 

机构地区：[1]广州市妇婴医院优生围产研究所,广州510180

出　　处：《现代临床医学生物工程学杂志》2002年第4期259-260,共2页Journal of Modern Clinical Medical Bioengineering

摘　　要：目的　探讨唐氏综合征产前筛查的方法以及影响其风险值的主要因素 .方法　用全自动时间荧光免疫分辨仪对 1198例怀孕 9～ 2 0周妇女进行血清妊娠相关血浆蛋白A(PAPP -A)、甲胎蛋白 (AFP )、游离绒毛膜促性腺激素Β亚基 (FREEβ-HCG)检测 .结果　风险率 1:2 5 0以上的孕妇 12 2例 ,其中 4 4例抽羊水或脐血进行染色体检测 ,有 2例确诊为阳性 ,而暂无 1例假阴性 .结论　血清PAPP -A、AFP、FREEβ -HCG的检测可作为唐氏筛查的优选生化项目 ,其血清水平以及母亲年龄、孕周、体重等是影响其风险值的主要因素 .Objective In order to study the method for screening Down's syndrome and assess interfering factor. Methods To determine the value of prenacy-associated plasma protein A (PAPP-A), free beta-human chorionic gonadotrophin (FREE β-HCG) and alpha-foetoprotein (AFP) in the serum of 1198 pregnant women at about 9th～20th weeks gestation with the auto time-resolved fluoroimmunoassay system. Results There were 122 women who had a fetus with risk of Down's syndrome above 1/250, among them, 44 pregnant women were done the pregnant diagnosis by amniocentesis and cordocentesis to check the chromosomal of the fetus.Two women had a fetus with Down's syndrome. Up to now, no trisomy 21 cases were missed by the screening method. Conclusions Serum measurements of PAPP-A, AFP and FREE β-HCG were the best choice method in screening Down's syndrome. The serum level of PAPP-A, AFP and FREE β-HCG in combination with pregnant women's age, weight and weeks of gestation were the main affected factors in assessing the risk.

关 键 词：唐氏综合征 产前筛查 妊娠相关血浆蛋白A 甲胎蛋白 游离绒毛膜促性腺激素β亚基 危险因素 常染色体病 

分 类 号：R714.55[医药卫生—妇产科学]