4-色满酮Mannich碱类化合物的合成及其水溶液的热稳定性研究  

Study on the synthesis and thermal stability in the aqueous solution of the Mannich bases of 4-chromanones

作　　者：胡春[1] 肖高铿[1] 王永永[1] 武龙[1] 计志忠[1] 刘百里[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016

出　　处：《中国药物化学杂志》2002年第5期268-271,共4页Chinese Journal of Medicinal Chemistry

基　　金：沈阳市科技局科技基金项目 (2 0 0 112 2 8- 0 9- 0 7)

摘　　要：目的设计合成一些 4 色满酮Mannich类化合物 ,并且考察其水溶液的稳定性。方法以取代的 4 色满酮为原料 ,经过Mannich反应合成 4 色满酮Mannich碱类化合物 ,并利用高效液相色谱法测定所合成的 4 色满酮Mannich碱类化合物的水溶液的稳定性。结果合成 3种 4 色满酮Mannich碱类化合物 ,并经元素分析 ,红外光谱 ,核磁共振氢谱确认了化合物结构 ,其水溶液在室温和 (37± 1)℃时 2 4h内均没有显著分解。Aim To design and synthesize some Mannich bases of 4 chromanones and study on their thermal stability in the aqueous solution.Methods The target Mannich bases of 4 chromanones were synthesized from 4 chromanones by using the Mannich reaction and their thermal stability in the aqueous solution was studied by the high performance liquid chromatography.Results 3 Mannich bases of 4 chromanones were synthesized and characterized by the elemental analysis,infrared spectra and proton NMR spectra,none of these compounds in the aqueous solution at room temperature and (37±1)℃ within 24 h has been decomposed obviously.

关 键 词：4-色满酮 Mannich碱类化合物 合成 水溶液 热稳定性 研究 

分 类 号：R914[医药卫生—药物化学]