瑞士乳杆菌TS206对小鼠血脂及粪便胆汁酸水平的调控影响  

Lactobacillus helveticus TS206 Regulates Serum Lipid Levels and Fecal Bile Acid Levels in Mice

作　　者：王泳[1] 叶雷[1] 贾彦[1] 庞广昌[1] 赵培[1] 闫亚丽[1] 陈庆森[1] WANG Yong;YE Lei;JIA Yan;PANG Guangchang;ZHAO Pei;YAN Yali;CHEN Qingsen(Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science,Tianjin University of Commerce, Tianjin 300134, China)

机构地区：[1]天津市食品生物技术重点实验室,天津商业大学生物技术与食品科学学院,天津300134

出　　处：《食品科学》2017年第11期196-201,共6页Food Science

基　　金：国家自然科学基金面上项目(31071522);天津市科技创新体系及条件平台建设项目(100005)

摘　　要：探讨瑞士乳杆菌TS206(Lactobacillus helveticus TS206)对小鼠血脂水平的影响。以健康BABL/c小鼠为对象,设置实验组和对照组,分别以L.helveticus TS206菌悬液和生理盐水(0.2 m L/d)连续灌胃7周,监测小鼠体质量和血脂(总胆固醇(total serum cholesterol,TC)、甘油三酯(triglycerides,TG)水平、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C))以及粪便总胆汁酸(total bile acid,TBA)水平的变化。灌胃L.helveticus TS206后,小鼠体质量增量显著高于对照组(P<0.05,P<0.01);血清中TC、TG和LDL-C水平均显著降低(P<0.05),灌胃停止1周后基本恢复到对照组水平;L.helveticus TS206菌悬液和生理盐水小鼠血清中HDL-C含量均无显著性变化;TBA水平呈先下降后上升趋势,且3周后TBA水平显著低于对照组(P<0.05)。研究结果表明,L.helveticus TS206能促进健康小鼠体质量增加,并有效调控其血脂水平,提示口服L.helveticus TS206菌剂可能会降低患心脑血管疾病的风险。In order to explore the effect of Lactobacillus helveticus TS206on serum lipid levels in mice,health BABL/cmice were divided into two groups.One group was given L.helveticus TS206bacterial suspension by gavage for7consecutiveweeks while the other was gavaged with normal saline as control.Body weight,serum lipid levels including total serumcholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C),and fecal total bile acid(TBA)levels were investigated in all mice.After the administration of L.helveticus TS206,body weight gains in mice were significantly higher than those in the control group(P<0.05,P<0.01),and the mean values ofTC,TG and LDL-C were significantly decreased(P<0.05),which were restored to normal a week after the administration ofL.helveticus TS206.There was no significant change in serum HDL-C concentrations between both groups(P>0.05).FecalTBA concentration decreased in the intervention group,reaching a value significantly lower than that in the control groupafter three weeks of administration,while it increased in the control group.This study demonstrated that L.helveticus TS206could promote body weight gain in healthy mice,and effectively regulate their serum lipid levels,suggesting that orallyadministered L.helveticus TS206may reduce the risk of cardiovascular and cerebrovascular diseases.

关 键 词：瑞士乳杆菌TS206 血脂 总胆汁酸 心脑血管疾病 

分 类 号：TS201.3[轻工技术与工程—食品科学]