果蔬中多酚类化合物双向调控Nrf2/Keap1信号通路的研究进展  

A Review of the Dual Role of Dietary Polyphenols from Fruits and Vegetables on Regulation of Nrf2/Keap1 Signaling

作　　者：赖灯妮 覃思[1] 赵玲艳[1] 邓放明[1] LAI Dengni;QIN Si;ZHAO Lingyan;DENG Fangming(College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China)

机构地区：[1]湖南农业大学食品科学技术学院,湖南长沙410128

出　　处：《食品科学》2018年第5期311-320,共10页Food Science

基　　金：湖南省研究生科研创新项目(CX2016B279);国家现代农业(特色蔬菜)产业技术体系建设专项(CARS-24-E-02);公益性行业(农业)科研专项(201303079);国家自然科学基金青年科学基金项目(31101268);湖南省教育厅优秀青年项目(13B047)

摘　　要：果蔬中含有丰富的多酚类化合物,其含有的酚羟基中邻位酚羟基极易被氧化,有较强捕捉活性氧等自由基的能力,因此能够清除自由基和淬灭活性氧。Nrf2(NF-E2-related factor 2)信号通路是增强机体抗氧化功能最重要的保护性信号途径,在细胞抵御氧化应激机制中有着重要的地位,是抗氧化研究领域的热点。本文通过阐述Nrf2/Keap1(Kelch-like ECH-associated protein 1)信号通路及其调节方式,讨论Nrf2在肿瘤化学预防和促进癌症发生中的双重作用,重点介绍和归纳了果蔬中几种典型的多酚类物质对Nrf2/Keap1信号通路双向调控作用的分子机制,以期为利用果蔬多酚开发健康绿色食品和药品提供一定的理论依据。Fruits and vegetables are rich in polyphenolic compounds,in which the ortho phenolic hydroxyl groups are easily oxidized and have a strong ability to capture free radicals such as reactive oxygen species.Thus,these compounds can remove free radicals and quench active oxygen.Nrf2(NF-E2-related factor2)/Keap1(Kelch-like ECH-associated protein1)signaling pathway is the most important protective signaling pathway to enhance antioxidant status in the body,which plays an important role in cellular antioxidant defense.In the present review,we describe Nrf2/Keap1signaling pathway and its regulatory mechanism.The dual role of the signaling pathway in cancer chemoprevention and carcinogenesis promotion is discussed as well.The focus of this review is on the molecular mechanism by which serval typical dietary polyphenols affect this dual regulation.We expect that this review will provide a theoretical basis for developing healthy green food products containing plant polyphenols.

关 键 词：果蔬 多酚类化合物 Nrf2/Keap1信号通路 双向调控作用 

分 类 号：TS201.4[轻工技术与工程—食品科学]