Mechanical-force-promoted peptide assembly: a general method  

作　　者：Yue Yuan Qi-Qi-Ge Du Yu-Jiao Wang Jun Hu Shi-Tao Lou Yi Zhang 

机构地区：[1]State Key Laboratory of Precision Spectroscopy, East China Normal University [2]Key Laboratory of Interfacial Physics and Technology,Shanghai Institute of Applied Physics, Chinese Academy of Sciences [3]School of Life Sciences, Inner Mongolia Agricultural University

出　　处：《Nuclear Science and Techniques》2018年第9期192-196,共5页核技术（英文）

基　　金：supported by the National Natural Science Foundation of China(No.11674344);the National Basic Research Program of China(973 program,No.2013CB932801);the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(No.QYZDJ-SSW-SLH019-2)

摘　　要：A general method was developed for promoting peptide assembly and protein polymerization to form nanoscale patterns on various surfaces with an atomic force microscope(AFM) operated in a liquid. By scanning solid surfaces with an AFM tip, we showed that peptide monomers assemble at a higher rate in the tip-scanned area compared to other regions. The promotion is attributed to the mechanical force applied by the scanning tip. This kind of mechanical-force-promoted assembly was also observed with different peptides on various substrates. The force promoting peptide assembly provides a simple and practical solution for preparing and building peptide and protein architectures for future nanodevices.A general method was developed for promoting peptide assembly and protein polymerization to form nanoscale patterns on various surfaces with an atomic force microscope(AFM) operated in a liquid. By scanning solid surfaces with an AFM tip, we showed that peptide monomers assemble at a higher rate in the tip-scanned area compared to other regions. The promotion is attributed to the mechanical force applied by the scanning tip. This kind of mechanical-force-promoted assembly was also observed with different peptides on various substrates. The force promoting peptide assembly provides a simple and practical solution for preparing and building peptide and protein architectures for future nanodevices.

关 键 词：Self-assembly PEPTIDE Nanomechanical STIMULUS Support LIPID BILAYERS Atomic FORCE MICROSCOPE 

分 类 号：TL[核科学技术]