肠道干细胞G蛋白耦联受体5的作用机制与影响因素  

Mechanism and influencing factors of Lgr5 in intestinal stem cells

作　　者：沈颖 郭红梅[1] 金玉[1] SHEN Ying;GUO Hong-mei;JIN Yu(Department of Gastroenterology,Children's Hospital Affiliated to Nanjing Medical University,Nanjing 210008,Jiangsu,China)

机构地区：[1]南京医科大学附属儿童医院消化科,南京医学硕士研究生210008

出　　处：《医学研究生学报》2018年第9期991-994,共4页Journal of Medical Postgraduates

基　　金：国家临床重点专科建设项目(卫办医政函[2011]873号)

摘　　要：位于隐窝基底部的含有亮氨酸重复序列的G蛋白耦联受体5(Lgr5)是肠道干细胞的标记物,以其独特的内化特性增强Wnt/β-catenin信号,通过Wnt/β-catenin信号通路调节肠道细胞增殖,利用IQGAP1影响肠道干细胞(ISCs)的细胞骨架以及细胞黏附力。此外,Lgr5还接受白细胞介素-1β(IL-1β)、IL-22、mi R-100-5p等影响因素的调节。而当隐窝中的肠道菌群消失时,Lgr5+ISCs异位于隐窝顶部,诱导细胞凋亡增加。因此,Lgr5受多种因素影响并发挥其独特的作用,在调节ISCs增殖分化和稳定中扮演重要角色。The leucine repeat-rich G-protein-coupled receptor 5(Lgr5),which expressed at the bottom of the crypt,not only acts as a marker of intestinal stem cells,but also induces cytonemes for transfering signaling effectors by internalization,influences proliferation by Wnt/β-catenin pathway,and promotes cytoskeletal structure,cell adhesion of intestinal stem cells(ISCs)via the IQGAP1.In addition,Lgr5 can be affected by the regulation of IL-1β、IL-22、miR-100-5p and others.Besides,intestinal microbiota change the localization of Lgr5+cells in cript to induce apoptosis increased.Therefore,Lgr5 is influenced by many factors,which may play an important role in the proliferation,differentiation and stability of ISCs.

关 键 词：G蛋白耦联受体5 肠道干细胞 内化 细胞黏附 肠道菌群 

分 类 号：R57[医药卫生—消化系统]