S6B-4 Roles of the Basal Ganglia in Sleep-Wake Regulation  

作　　者：HUANG Zhi-li 

机构地区：[1]Department of Pharmacology,School of Basic Medical Sciences State Key Laboratory of Medical Neurobiology Institutes of Brain Science and Collaborative Innovation Center for Brain Science,Shanghai Medical College,Fudan University,Shanghai,200032,China

出　　处：《神经药理学报》2018年第4期97-98,共2页Acta Neuropharmacologica

摘　　要：The basal ganglia(BG)act as a cohesive functional unit that regulates motor function,habit formation,and reward/addictive behaviors.However,it is still not well understood how the BG maintains wakefulness and suppresses sleep to achieve all these fundamental functions until genetically engineered systems developed these years.We focused on the adenosine A2A and dopamine D1 Receptors(R)in the BG and obtained following 4 findings:①Nucleus accumbens(NAc)dopamine D1R-expressing neurons are essential in controlling wakefulness and are involved in physiological arousal via the lateral hypothalamus and midbrain circuits;②The rostromedial tegmental nucleus(RMTg),also called the GABAergic tail of the ventral tegmental area,projects to the midbrain dopaminergic system and other regions.Our findings reveal an essential role of the RMTg in the promotion of non-rapid eye movement(non-REM,NREM)sleep and homeostatic regulation;③Opposite to the D1R in the NAc,A2AR made a prominent contribution to sleep control associated with motivation.④Striatal adenosine A2AR neurons control active-period sleep via parvalbumin neurons in external globus pallidus.Taken together,we proposed a plausible model in which the caudate-putamen and NAc integrate behavioral processes with sleep/wakefulness through adenosine and dopamine receptors.The impacts of the BG in physiological sleep and insomnia will be discussed.

关 键 词：ADENO-ASSOCIATED virus OPTOGENETICS DREADD BASAL GANGLIA SLEEP-WAKE REGULATION 

分 类 号：R73[医药卫生—肿瘤]