Supported by Hungarian National Research,Development and Innovation Fund Projects,No.GINOP-2.3.3-15-2016-00006;Hungarian NKFIH Fund Project,No.FK131789(to Bódi N);János Bolyai Research Scholarship of the Hungarian Academy of Sciences(to Bódi N);ÚNKP-21-5-New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research,Development and Innovation Fund(to Bódi N);Gedeon Richter Plc Centenary Foundation(to Bódi N).
BACKGROUND Cytokines are essential in autoimmune inflammatory processes that accompany type 1 diabetes.Tumor necrosis factor alpha plays a key role among others in modulating enteric neuroinflammation,however,it has a...
Supported by Inheritance and Innovation in TCM“Hundred-Thousand-Ten Thousand”Talent Project(Qinhuang Project)(No.F119090038);the National Natural Science Foundation of China(Based on the Cascade Reaction of Microglia-Astrocyte research exosomal mi RNA mechanisms of the inhibitory transition from acute to chronic pain of LDH by electroacupuncture,No.82074529);Scientific Research Projects of Traditional Chinese Medicine Bureau of Guangdong Province(Based on the cAMP-PKA-HCN2 pathway the mechanism of electro-acupuncture to prevent the development of pain in lumbar disc herniation,No.20211254)
OBJECTIVE:To explore the mechanisms of dorsal root ganglia and spinal microglia cascade cross in electroacupuncture(EA)analgesia in the treatment of lumbar disc herniation.METHODS:A rat model of lumbar disc herniation...
Supported by Chonnam National University Hospital Research Institute of Clinical Medicine,No.BCRI20023.
BACKGROUND Cytomegalovirus(CMV)colitis is usually seen in immunocompromised patients with risk factors such as human immunodeficiency virus infection,solid organ transplant,inflammatory bowel disease,or malignancy.The...
European Union and the Hungarian Government in the framework,No.EFOP-3.6.1-16-2016-00008;Hungarian NKFIH fund project,No.FK131789(to Bódi N);János Bolyai Research Scholarship of the Hungarian Academy of Sciences(to Bódi N);and New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research,Development and Innovation Fund,No.ÚNKP-20-5(to Bódi N).
BACKGROUND The importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy. Regionally distinct thickening of endothelial basement membrane(BM) of intes...
supported by grants from Shenzhen Overseas High-Caliber Peacock Foundation KQTD2015071414385495;Shenzhen Science and Innovation Commission Project Grants JCYJ20180306173333907 to Shenzhen International Institute for Biomedical Research。
On entering sensory ganglia,herpes simplex viruses 1(HSV-1)establishes a latent infection with the synthesis of a latency associated transcript(LAT)or initiates productive infection with expression of a set of immedia...
Supported by Natural Science Foundation of China(No.81904127/H2708);Study on Mechanism of Chanqin Granules Inhibiting TRPV1 Channel Activity in Relieving the Airway Neurogenic Inflammation of Post-Infectious Cough Based on Inos/NO-Cgmp-PKG Signal Pathway
OBJECTIVE:To investigate the efficacy of active compounds of Chanqin(CQ)granules on PM2.5-induced airway neurogenic inflammation in vivo,and to elucidate the underlying mechanisms of action.METHODS:The Traditional Chi...
In Parkinson’s disease (PD), dopaminergic neurons reduce the regulation of glutamatergic (glutamate-Glu) input from the cortex to neostriatum (caudate and putamen nuclei) consequently leading to a hyperactivity of gl...
Supported by start-up funds from Van Andel Institute(to HYC);The author thanks David Nadziejka for technical editing assistance.
Parkinson’s disease (PD) is a progressive neurodegenerative disease, which causes a tremendous socioeconomic burden. PD patients are suffering from debilitating motor and nonmotor symptoms. Cardinal motor symptoms of...
Supported by Fondazione del Monte di Bologna e Ravenna(ID ROL:Fd M/3208)
BACKGROUND Mesenchymal stromal cell(MSC)-based therapy is currently under study to treat inflammatory bowel diseases.MSC bioactive products could represent a valid alternative to overcome issues associated with system...