In Parkinson’s disease (PD), dopaminergic neurons reduce the regulation of glutamatergic (glutamate-Glu) input from the cortex to neostriatum (caudate and putamen nuclei) consequently leading to a hyperactivity of gl...
Currently, the most common surgical treatment for Parkinson's disease is deep brain stimulation(DBS). This treatment strategy is typically reserved for bradykinesia, rigidity and tremor in patients who no longer re...
Objective To assess postoperative effects of microelectrode-guided postoventral pallidotomy (PVP) for Parkinson ’ s disease. Methods Intraoperative microelectrode recordings and microstimulation were used to explore ...
Objective To study the methods and outcome of 71 patients with Parkinson’s disease treated with microelectrode-guided stereotactic pallidotomy and thalamotomy.Method Pallidal and thalamal target sites are chosen by ...
Objective: To investigate the short- and long-term efficacy of microelectrode-guided, posteroventral pallidotomy (PVP) in a large cohort of patients with advanced Parkinson's disease (PD). Background.: Advances in mot...