Case of human immunodeficiency virus infection presenting as a tip variant of focal segmental glomerulosclerosis: A case report and review of the literature  

作　　者：Daiki Goto Naro Ohashi Asumi Takeda Yoshihide Fujigaki Akira Shimizu Hideo Yasuda Kazuhisa Ohishi 

机构地区：[1]Internal Medicine 1, Hamamatsu University School of Medicine [2]Division of Nephrology,Hamamatsu Medical Center [3]Department of Internal Medicine, Teikyo University School of Medicine [4]Department of Pathology, Nihon University School of Medicine

出　　处：《World Journal of Nephrology》2018年第4期90-95,共6页世界肾病学杂志（英文版）

摘　　要：The incidence of the collapsing variant of focal segmental glomerulosclerosis(FSGS) as a human immunodeficiency virus(HIV)-associated nephropathy has reduced since the introduction of antiretroviral therapy(ART). However, the incidence of other variants of FSGS, except for the collapsing variant, is increasing, and its therapeutic strategies remain uncertain. A 60-year-old HIV infected man in remission with ART was admitted for progressive renal insufficiency and nephrotic-ranged proteinuria. Renal biopsy revealed a tip variant of FSGS and his clinical manifestations resolved with corticosteroid therapy. HIV infected patients might develop non-collapsing FSGS, including tip variant of FSGS and corticosteroid therapy might be effective for them. A renal biopsy might be essential to determine the renal histology and to decide on corticosteroid therapy.The incidence of the collapsing variant of focal segmental glomerulosclerosis(FSGS) as a human immunodeficiency virus(HIV)-associated nephropathy has reduced since the introduction of antiretroviral therapy(ART). However, the incidence of other variants of FSGS, except for the collapsing variant, is increasing, and its therapeutic strategies remain uncertain. A 60-year-old HIV infected man in remission with ART was admitted for progressive renal insufficiency and nephrotic-ranged proteinuria. Renal biopsy revealed a tip variant of FSGS and his clinical manifestations resolved with corticosteroid therapy. HIV infected patients might develop non-collapsing FSGS, including tip variant of FSGS and corticosteroid therapy might be effective for them. A renal biopsy might be essential to determine the renal histology and to decide on corticosteroid therapy.

关 键 词：Focal segmental GLOMERULOSCLEROSIS TIP VARIANT ANTIRETROVIRAL THERAPY CORTICOSTEROID THERAPY Human immunodeficiency virus 

分 类 号：R[医药卫生]