Public Welfare Technology Application Research Program of Zhejiang Province:Study on the Application of Phellinus linteus Protocatechualdehyde in Inhibiting Glomerular Extracellular Matrix Accumulation based on TSP-1 Double Luciferase Reporting System(No.LGC21H290002);Key Projects of Zhejiang Administration of Traditional Chinese Medicine:Quality and Safety Evaluation of Cultivated Phellinus linteus in Zhejiang Province and its Comprehensive Application in the Prevention and Treatment of Kidney Disease(No.2020ZZ016)。
OBJECTIVE:To explore the underlying molecular mechanism of Phellinus linteus(P.linteus).METHODS:We used a tandem mass tag-based quantitative proteomic method to determine the differentially expressed proteins.Network ...
supported by the Public Welfare Technology Application Research Program of Zhejiang Province (LGC21H290002);Key Projects of Zhejiang Administration of Traditional Chinese Medicine (2020ZZ016).
Objective:To comparatively investigate the ameliorative effect of Phellinus igniarius(P.igniarius)on renal aging in a rat model of focal and segmental glomerulosclerosis(FSGS).Methods:The FSGS model was established in...
Introduction: Focal Segmental Glomerulosclerosis (FSGS) corresponds to a clinicopathological syndrome, manifested by generally abundant proteinuria associated with hyaline deposits on part of certain glomeruli and spa...
BACKGROUND Crumbs homolog 2(CRB2)is a recently discovered gene that is closely related to the maintenance of normal polarity in podocytes;mutations can directly lead to steroid-resistant nephrotic syndrome(SRNS).Howev...
Objective To explore the relationship between segmental glomerulosclerosis and the change of renal function in IgA nephropathy (IgAN).Methods It was a single-center retrospective cohort study.The patients with biopsy-...
Nephrotic syndrome is a relatively common clinical disease.Associated dyslipidemia is a risk factor for the occurrence and development of cardiovascular and renal diseases that might gradually develop into atheroscler...
Therapeutic apheresis is a cornerstone of therapy for several conditions in transplantation medicine and is available in different technical variants. In the setting of kidney transplantation, immunological barriers s...
supported by Networking Resource Centre in Biological Sciences (NRCBS; funded by UGC, Govt. of India)
Nephrotic syndrome is one of the most common childhood kidney diseases. It is mostly found in the age group of 2 to 8 years. Around 10%-15% of nephrotic syndrome cases are non-responders of steroid treatment(SRNS).Ang...
Background:Focal segmental glomerulosclerosis (FSGS)is a kidney disease that is commonly associated with proteinuria and the progressive loss of renal function,which is characterized by podocyte injury and the depleti...
The incidence of the collapsing variant of focal segmental glomerulosclerosis(FSGS) as a human immunodeficiency virus(HIV)-associated nephropathy has reduced since the introduction of antiretroviral therapy(ART). Howe...