Progress of research on dyslipidemia accompanied by nephrotic syndrome  

作　　者：Min Tao Hai-Ping Wang Jing Sun Jing Tian 

机构地区：[1]Department of Nephrology,Shandong Provincial Hospital,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan,Shandong 250021,China

出　　处：《Chronic Diseases and Translational Medicine》2020年第3期182-187,共6页慢性疾病与转化医学（英文版）

摘　　要：Nephrotic syndrome is a relatively common clinical disease.Associated dyslipidemia is a risk factor for the occurrence and development of cardiovascular and renal diseases that might gradually develop into atherosclerosis,glomerulosclerosis or tubulointerstitial injury.It also confers an elevated risk of complications such as thromboembolism.If not properly controlled over the long term,dyslipidemia will become a key factor in a poor prognosis.Furthermore,dyslipidemia correlates with an increase in hepatic compensatory synthetic lipoprotein levels and a decrease in lipoprotein clearance,which can be sourced to the downregulation of hepatic and lipoprotein lipase activities in endothelial cells,muscle,and adipose tissue,and clinically characterized as hypertriglyceridemia or hypercholesterolemia.However,further investigations into the mechanism(s)of dyslipidemia are needed,with the resultant detailed perspectives and analyses substantially aiding the further development of treatment guidelines.Currently,statins represent the most popular type of pharmaceutical intervention because they lower hepatic cholesterol production and promote the absorption of low-density lipoprotein-cholesterol from the bloodstream,followed by second-line and other potential therapies to regulate the expression of specific receptors.

关 键 词：Nephrotic syndrome DYSLIPIDEMIA ATHEROSCLEROSIS GLOMERULOSCLEROSIS STATINS 

分 类 号：R589.2[医药卫生—内分泌] R692[医药卫生—内科学]