Gastro-oesophageal reflux disease and eosinophilic oesophagitis: What is the relationship?  

作　　者：Stephanie Wong Andrew Ruszkiewicz Richard H Holloway Nam Q Nguyen 

机构地区：[1]Discipline of Medicine, University of Adelaide [2]Department of Gastroenterology and Hepatology, Royal Adelaide Hospital [3]Anatomical Pathology, SA Pathology

出　　处：《World Journal of Gastrointestinal Pathophysiology》2018年第3期63-72,共10页世界胃肠病理生理学杂志（英文版）（电子版）

摘　　要：Eosinophilic oesophagitis(EoE) and gastro-oesophageal reflux disease(GORD) are the most common causes of chronic oesophagitis and dysphagia associated with oesophageal mucosal eosinophilia. Distinguishing between the two is imperative but challenging due to overlapping clinical and histological features. A diagnosis of EoE requires clinical, histological and endoscopic correlation whereas a diagnosis of GORD is mainly clinical without the need for other investigations. Both entities may exhibit oesophageal eosinophilia at a similar level making a histological distinction between them difficult. Although the term proton-pump inhibitor responsive oesophageal eosinophilia has recently been retracted from the guidelines, a relationship between Eo E and GORD still exists. This relationship is complex as they may coexist, either interacting bidirectionally or are unrelated. This review aims to outline the differences and potential relationship between the two conditions, with specific focus on histology, immunology, pathogenesis and treatment.Eosinophilic oesophagitis(EoE) and gastro-oesophageal reflux disease(GORD) are the most common causes of chronic oesophagitis and dysphagia associated with oesophageal mucosal eosinophilia. Distinguishing between the two is imperative but challenging due to overlapping clinical and histological features. A diagnosis of EoE requires clinical, histological and endoscopic correlation whereas a diagnosis of GORD is mainly clinical without the need for other investigations. Both entities may exhibit oesophageal eosinophilia at a similar level making a histological distinction between them difficult. Although the term proton-pump inhibitor responsive oesophageal eosinophilia has recently been retracted from the guidelines, a relationship between Eo E and GORD still exists. This relationship is complex as they may coexist, either interacting bidirectionally or are unrelated. This review aims to outline the differences and potential relationship between the two conditions, with specific focus on histology, immunology, pathogenesis and treatment.

关 键 词：Relationship PATHOGENESIS EOSINOPHILIC OESOPHAGITIS HISTOLOGICAL features Gastro-oesophageal REFLUX disease 

分 类 号：R[医药卫生]