Epitranscriptomics of cancer  

作　　者：Marina Tusup Thomas Kundig Steve Pascolo 

机构地区：[1]Department of Dermatology,University Hospital of Zürich [2]Faculty of Medicine, University of Zurich

出　　处：《World Journal of Clinical Oncology》2018年第3期42-55,共14页世界临床肿瘤学杂志（英文版）

基　　金：Supported by University of Zurich:"URPP:Translational Cancer research";the"MERIT"project supported by the FP7 European Union’s Research;Innovation Funding program

摘　　要：The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opposite effects of RNA modifications have been reported.Some RNA modifications promote,while ot-hers decrease the growth and invasiveness of cancer.The present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine,Pse-udouridine,Inosine,2’O-methylation or methylcytidine in cancer’s RNA.It also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications,whereby modulating dynamic RNA modifications may be a new method to treat cancer.The functional impact of modifications of cellular RNAs, including m RNAs, mi RNAs and lnc RNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported. Some RNA modifications promote, while ot-hers decrease the growth and invasiveness of cancer. The present manuscript reviews the current knowledge on the potential impacts of N6--Methyladenosine, Pse-udouridine, Inosine, 2'-O-methylation or methylcytidine in cancer's RNA. It also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications, whereby modulating dynamic RNA modifications may be a new method to treat cancer.

关 键 词：RNA modifications N6-methyladenosine 5-methylcytidine 2’O-methylation or methylcytidine PSEUDOURIDINE INOSINE 

分 类 号：R[医药卫生]