How best to manage gastrointestinal stromal tumor  

作　　者：Gandhi Lanke Jeffrey H Lee 

机构地区：[1]Department of Gastroenterology,Hepatology and Nutrition,University of Texas MD Anderson Cancer Center

出　　处：《World Journal of Clinical Oncology》2017年第2期135-144,共10页世界临床肿瘤学杂志（英文版）

摘　　要：Gastrointestinal stromal tumors(GISTs) are rare but most common nonepithelial tumor of gastrointestinal tract. They are often found incidentally on computed tomography and endoscopic investigations. Increasing knowledge of the pathogenesis of GISTs and the advent of tyrosine kinase inhibitors revolutionized the management of GISTs. The newer advanced endoscopic techniques have challenged the conventional surgery although the true efficacy and safety of endoscopic approach is not clear at this time. This review article focuses on pathogenesis, diagnosis and management of GISTs.Gastrointestinal stromal tumors(GISTs) are rare but most common nonepithelial tumor of gastrointestinal tract. They are often found incidentally on computed tomography and endoscopic investigations. Increasing knowledge of the pathogenesis of GISTs and the advent of tyrosine kinase inhibitors revolutionized the management of GISTs. The newer advanced endoscopic techniques have challenged the conventional surgery although the true efficacy and safety of endoscopic approach is not clear at this time. This review article focuses on pathogenesis, diagnosis and management of GISTs.

关 键 词：Gastrointestinal STROMAL tumor Endoscopy Endoscopic ultrasound-fine-needle ASPIRATION TYROSINE kinase inhibitor IMATINIB 

分 类 号：R735[医药卫生—肿瘤]