Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer  

作　　者：Kazuki Moro Masayuki Nagahashi Rajesh Ramanathan Kazuaki Takabe Toshifumi Wakai 

机构地区：[1]Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences [2]Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and the Massey Cancer Center

出　　处：《World Journal of Clinical Cases》2016年第7期155-164,共10页世界临床病例杂志

基　　金：Supported by The Japan Society for the Promotion of Science(JSPS)Grant-in-Aid for Scientific Research,Nos.15H05676 and 15K15471 for Nagahashi M and No.15H04927 for Wakai T;supported by the Uehara Memorial Foundation,Nakayama Cancer Research Institute,Takeda Science Foundation,Tsukada Medical Foundation;supported by NIH/NCI,No.R01CA160688;supported by Susan G.Komen Investigator Initiated Research,No.IIR12222224;supported by Tohoku Cancer Professional Training Promotion Plan

摘　　要：Inflammation is a central process in several disorders and contributes to cancer progression. Inflammation involves a complex cascade of pro-inflammatory and anti-inflammatory signaling events with protein and lipid mediators. Recent advances in lipid detection have revealed the importance of lipid mediators in inflammation. Omega three polyunsaturated fatty acids(ω-3 PUFA) are found naturally in fish oil and have been extensively studied in multiple inflammatory diseases with improved outcomes. Resolvins are thought to be the active metabolites of ω-3 PUFA, and are responsible for facilitating the resolving phase of acute inflammation. Clinically, resolvins have been associated with resolution of acute kidney injury and acute lung injury, micro and macro vascular response to injury, and inhibition of microglia-activated inflammation in neurodegenerative disorders. In addition to inflammatory diseases, ω-3 PUFA and resolvins appear to modulate cancer progression. ω-3 PUFA intake has been associated with reduced inflammation in colorectal cancer, and favorable phenotype in breast cancer. Resolvins offer promising therapeutic potential as they may modulate inflammation with minimal side-effects, in contrast to currently available anti-inflammatory medications. This review describes the roles of ω-3 PUFA and resolvins in the inflammatory cascade, various inflammatory diseases, and specific cancers. Additionally, it will discuss the clinical therapeutic potential of resolvins astargets in inflammatory diseases and cancers.Inflammation is a central process in several disorders and contributes to cancer progression. Inflammation involves a complex cascade of pro-inflammatory and anti-inflammatory signaling events with protein and lipid mediators. Recent advances in lipid detection have revealed the importance of lipid mediators in inflammation. Omega three polyunsaturated fatty acids(ω-3 PUFA) are found naturally in fish oil and have been extensively studied in multiple inflammatory diseases with improved outcomes. Resolvins are thought to be the active metabolites of ω-3 PUFA, and are responsible for facilitating the resolving phase of acute inflammation. Clinically, resolvins have been associated with resolution of acute kidney injury and acute lung injury, micro and macro vascular response to injury, and inhibition of microglia-activated inflammation in neurodegenerative disorders. In addition to inflammatory diseases, ω-3 PUFA and resolvins appear to modulate cancer progression. ω-3 PUFA intake has been associated with reduced inflammation in colorectal cancer, and favorable phenotype in breast cancer. Resolvins offer promising therapeutic potential as they may modulate inflammation with minimal side-effects, in contrast to currently available anti-inflammatory medications. This review describes the roles of ω-3 PUFA and resolvins in the inflammatory cascade, various inflammatory diseases, and specific cancers. Additionally, it will discuss the clinical therapeutic potential of resolvins astargets in inflammatory diseases and cancers.

关 键 词：ANTI-INFLAMMATORY lipid MEDIATORS Resolvin OMEGA THREE polyunsaturated fatty acids Inflammatory diseases CANCER 

分 类 号：R363[医药卫生—病理学]