Epilepsy associated tumors: Review article  

作　　者：Marco Giulioni Gianluca Marucci Matteo Martinoni Anna Federica Marliani Francesco Toni Fiorina Bartiromo Lilia Volpi Patrizia Riguzzi Francesca Bisulli Ilaria Naldi Roberto Michelucci Agostino Baruzzi Paolo Tinuper Guido Rubboli 

机构地区：[1]IRCCS Institute of Neurological Sciences of Bologna, Division of Neurosurgery, Bellaria Hospital, 40139 Bologna, Italy [2]Department of Biomedical and Neuromotor Sciences (DiBiNeM), Section of Pathology "M.Malpighi", Bellaria Hospital, University of Bologna, 40139 Bologna, Italy [3]IRCCS Institute of Neurological Sciences of Bologna, Section of Neuroradiology, Bellaria Hospital, 40139 Bologna, Italy [4]Department of Specialistic Diagnostic and Experimental Medicine (DIMES), Section of Neuroradiology,University of Bologna, 40139 Bologna Italy [5]IRCCS Institute of Neurological Sciences of Bologna,Division of Neurology, Bellaria Hospital, 40139 Bologna, Italy [6]IRCCS Institute of Neurological Sciences of Bologna,Bellaria Hospital, 40139 Bologna, Italy [7]Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139 Bologna Italy [8]Danish Epilepsy Centre, Epilepsi hospitalet,4293 Dianalund, Denmark

出　　处：《World Journal of Clinical Cases》2014年第11期623-641,共19页世界临床病例杂志

摘　　要：Long-term epilepsy associated tumors(LEAT) represent a well known cause of focal epilepsies. Glioneuronaltumors are the most frequent histological type consisting of a mixture of glial and neuronal elements and most commonly ariseing in the temporal lobe. Cortical dysplasia or other neuronal migration abnormalities often coexist. Epilepsy associated with LEAT is generally poorly controlled by antiepileptic drugs while, on the other hand, it is high responsive to surgical treatment. However the best management strategy of tumor-related focal epilepsies remains controversial representing a contemporary issues in epilepsy surgery. Temporo-mesial LEAT have a widespread epileptic networkwith complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy LEAT may have an excellent seizure outcome therefore surgical treatment should be offered early, irrespective of pharmacoresistance, avoiding both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of malignant transformation.Long-term epilepsy associated tumors(LEAT) represent a well known cause of focal epilepsies. Glioneuronaltumors are the most frequent histological type consisting of a mixture of glial and neuronal elements and most commonly ariseing in the temporal lobe. Cortical dysplasia or other neuronal migration abnormalities often coexist. Epilepsy associated with LEAT is generally poorly controlled by antiepileptic drugs while, on the other hand, it is high responsive to surgical treatment. However the best management strategy of tumor-related focal epilepsies remains controversial representing a contemporary issues in epilepsy surgery. Temporo-mesial LEAT have a widespread epileptic networkwith complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy LEAT may have an excellent seizure outcome therefore surgical treatment should be offered early, irrespective of pharmacoresistance, avoiding both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of malignant transformation.

关 键 词：EPILEPSY Low GRADE TUMORS Long-term EPILEPSY ASSOCIATED TUMORS Glioneuronal TUMORS GANGLIOGLIOMA Dysembryoplastic NEUROEPITHELIAL tumor Lesionectomy EPILEPSY surgery 

分 类 号：R742.1[医药卫生—神经病学与精神病学]